3 documents found, page 1 of 1
Endothelial activation is associated with albuminuria in multibacillary leprosy
Tessarolo, Louise Donadello; Meneses , Gdayllon Cavalcante; Bezerra, Gabriela Freire; Rocha, Thaiany Pereira da; Azevedo, Isabella Evelyn Prado deLeprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 t...
Betulinic acid induces cell death by necrosis in Trypanosoma cruzi
Sousa, Paloma Leão; Souza, Racquel Oliveira da Silva; Tessarolo, Louise Donadello; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Sampaio, Tiago LimaChagas ’ disease is a neglected disease caused by the protozoan parasite Trypanosoma cruzi and constitutes a serious health problem worldwide. The treatment is limited, with variable e ffi cacy of benznidazole and ni- furtimox. Betulinic Acid (BA), a triterpene, can be found in medicinal herbs and has a wide variety of biological and pharmacological activities. The objective was to evaluate betulinic acid e ff ...
Estudo in vitro da atividade tripanocida de nanopartículas de benzonidazol em c...
Tessarolo, Louise DonadelloThe Chagas disease is a major public health problem, affecting about 6 million people worldwide and causes high morbidity and mortality in affected populations. The benznidazole (BZ), the drug used in the treatment has limited effectiveness and cause serious adverse effects. The drug transport by nanoparticles has demonstrated efficacy as the controlled and targeted release of pharmacological molecules, in addi...