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Loss of Dkk-1 in osteocytes mitigates alveolar bone loss in mice with periodont...

Goes, Paula; Dutra, Caio; Lösser, Lennart; Hofbauer, Lorenz C.; Rauner, Martina; Thiele, Sylvia

Background: Periodontitis is a highly prevalent infection-triggered inflammatory disease that results in bone loss. Inflammation causes bone resorption by osteoclasts, and also by suppression of bone formation via increase of Dickkopf-1 (Dkk-1), an inhibitor of Wnt signaling. Here, we tested the hypothesis that osteocytic Dkk-1 is a key factor in the pathogenesis of periodontitis-induced alveolar bone loss (ABL...

Date: 2020   |   Origin: Oasisbr
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