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Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses
Vasili, Eftychia; König, Annekatrin; Al-Azzani, Mohammed; Bosbach, Clara; Gatzemeier, Luisa Maria; Thom, Searlait; Chegão, Ana; Vicente Miranda, HugoPublisher Copyright: © The Author(s) 2025.; The risk of developing Parkinson’s disease (PD) is elevated in individuals with type 2 diabetes (T2DM), but the molecular pathways underlying this link remain unclear. Glycation, a non-enzymatic modification of lysine and arginine residues by reducing sugars or reactive dicarbonyls, may disrupt proteostasis and trigger pathology. Here, we investigated how methylglyoxa...
Data: 2025
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Origem: Repositório Institucional da UNL