4 documents found, page 1 of 1
Primary culture macrophages from fish as potential experimental model in toxici...
Silva, Isabella Ferreira; Papa, Letícia Fagundes; Carneiro, Pedro Gontijo; Schnitzler, Mariane Cristina; Andrade, Silmara NunesMultiwalled carbon nanotube (MWCNT) has been broadly used in several sectors of society. This material when exposed to the environment might reach the aquatic animals and cause toxic effects. Here, it was evaluated the MWCNTs toxicity in melanomacrophages primary culture that was submitted to 1 µ gm L-1 MWCNTs for 24 hours. After exposition to MWCNT, 48 and 59% liver and spleen melanomacrophages were healthy, r...
WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells b...
Silva, Ana Gabriela; Lopes, Caio Fabio Baeta; Carvalho Júnior, Clóvis Gomes; Thomé, Ralph Gruppi; Santos, Hélio Batista dos; Reis, R. M.Despite the standard approaches to treat the highly aggressive and invasive glioblastoma (GBM), it remains incurable. In this sense, cannabinoids highlight as a promising tool, because this tumor overexpresses CB1 and/or CB2 receptors and being, therefore, can be susceptible to cannabinoids treatment. Thus, this work investigated the action of the cannabinoid agonist WIN55-212-2 on GBM cell lines and non-malign...
Immunohistochemical, morphological and histometrical analyses of follicular dev...
Marcon, Lucas; Thomé, Ralph Gruppi; Mounteer, Ann Honor; Bazzoli, Nilo; Rizzo, Elizete; Benjamin, Laércio dos AnjosThiodan® is an organochlorine insecticide used in agriculture that can reach aquatic ecosystems where it can affect fish reproduction. This research aimed to evaluate follicular development and the expression of integrin β1, collagen type IV and caspase 3 by morphological, histometrical and immunohistochemical analyses of Astyanax bimaculatus exposed to Thiodan®. Treatments included three sublethal concentratio...
Immunohistochemical expression of collagens in the skin of horses treated with ...
Souza, Maria Verônica de; Silva, Mariana Brettas; Pinto, José de Oliveira; Crepaldi, Júlio; Lima, Marianna Barros de SouzaThis study evaluated the immunohistochemical expression of type I (COL I) and III (COL III) collagens during the healing process of skin treated with leukocyte-poor platelet-rich plasma (LP-PRP). Seven healthy gelding crossbred horses aged 16 to 17 years were used. Two rectangle-shaped wounds were created surgically in the right and left gluteal regions. Twelve hours after wound induction, 0.5 mL of the LP-PRP ...