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Synthesis and antiproliferative activity of C-3 functionalized Isobenzofuran-1(...

Teixeira, Róbson Ricardo; Bressan, Gustavo Costa; Pereira, Wagner Luiz; Ferreira, Joana Gasperazzo; Oliveira, Fabrício Marques de

A series of thirteen C-3 functionalized isobenzofuran-1(3H)-ones (phtalides) was synthesized via condensation, aromatization, and acetylation reactions. NMR (one and two dimensional experiments), IR, and mass spectrometry analysis allowed confirmation of the identity of the synthesized compounds. The substances were submitted to in vitro bioassays against U937 (lymphoma) and K562 (myeloid leukemia) cancer cell ...

Date: 2017   |   Origin: Oasisbr
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