39 documents found, page 1 of 4
Suicidal ideation, anxiety, and depression in patients with multiple sclerosis
Tauil,Carlos Bernardo; Grippe,Talyta Cortez; Dias,Ronaldo Maciel; Dias-Carneiro,Rafael Paternò Castello; Carneiro,Narel MoitaABSTRACT Psychiatric disorders frequently occur in patients with multiple sclerosis (MS); however, limited reports are available on these comorbidities. We aimed to investigate the relationships among MS, anxiety, depression, and suicidal ideation. Methods: One hundred and thirty two patients with relapsing-remitting MS were evaluated using the Expanded Disability Status Scale, Beck Depression Inventory-II (BDI...
Characterization of the first symptoms of multiple sclerosis in a Brazilian cen...
Cavenaghi,Vitor Breseghello; Dobrianskyj,Fernanda Martinho; Olival,Guilherme Sciascia do; Carneiro,Rafael Paternò Castello Dias; Tilbery,Charles PeterABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian r...
The cerebrospinal fluid in multiple sclerosis: far beyond the bands
Domingues,Renan Barros; Fernandes,Gustavo Bruniera Peres; Leite,Fernando Brunale Vilela de Moura; Tilbery,Charles Peter; Thomaz,Rodrigo BarbosaABSTRACT The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emer...
Olfactory alterations in patients with multiple sclerosis
Jordy,Sergio Semeraro; Starzewski Junior,Alberto; Macedo,Felipe André Basso; Manica,Gabriela Reginatto; Tilbery,Charles PeterABSTRACT This cross-sectional study involves 100 multiple sclerosis (MS) and 100 non-MS patients, under the age of 60 years old, with nasal obstruction, traumatic brain injury, previous rhinoplasty or neurosurgery, and so forth. Objective To assess olfactory function using the Connecticut test and verify correlations between olfactory alteration, disease duration and the Expanded Disability Status Scale (EDSS)....
Diplopia como primeiro sintoma de esclerose múltipla
Frazão,Maria Auxiliadora Monteiro; Lui,Aline Cristina F.; Tilbery,Charles Peter; Ejzenbaum,Fábio; Cohen,RalphObjetivo: Determinar a frequência e as características clínicas das alterações da motilidade ocular extrínseca em indivíduos portadores de esclerose múltipla, residentes no estado de São Paulo, em série de casos consecutivos de 1996 a 2011. Métodos: Foram selecionados oitenta e três indivíduos com esclerose múltipla, com idade entre 17 e 59 anos. Todos foram submetidos à anamnese e exame ocular completo. Result...
Validation and cross-cultural adaptation of sexual dysfunction modified scale i...
Silva,Raquel Ataíde Peres da; Olival,Guilherme Sciascia do; Stievano,Lívia Palma; Toller,Vania Balardin; Jordy,Sergio Semeraro; Eloi,MarinaMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). These patients suffer from various comorbidities, including sexual dysfunction (SD). The lesions of MS may affect regions of the CNS along the pathway of sexual response. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a scale that assesses sexual dysfunction. Adapt and validate the MSISQ-...
Medication withdrawal may be an option for a select group of patients in relaps...
Olival,Guilherme Sciascia do; Cavenaghi,Vitor Breseghello; Serafim,Vitor; Thomaz,Rodrigo Barbosa; Tilbery,Charles PeterThis article describes the clinical and radiological evolution of a stable group of patients with relapsing-remitting multiple sclerosis that had their disease-modifying therapy (DMT) withdrawn. Forty patients, which had made continuous use of one immunomodulator and had remained free of disease for at least 5 years, had their DMT withdrawn and were observed from 13 to 86 months. Out of the followed patients, 4...
Multiple sclerosis and herpesvirus interaction
Olival,Guilherme Sciascia do; Lima,Bruna Mendonca; Sumita,Laura M.; Serafim,Vitor; Fink,Maria Cristina; Nali,Luis Henrique; Romano,Camila MaltaMultiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is ...
Central nervous system infectious diseases mimicking multiple sclerosis: recogn...
Rocha,Antonio Jose da; Littig,Ingrid Aguiar; Nunes,Renato Hoffmann; Tilbery,Charles PeterThe current diagnostic criteria for multiple sclerosis (MS) confirm the relevant role of magnetic resonance imaging (MRI), supporting the possibility of characterizing the dissemination in space (DIS) and the dissemination in time (DIT) in a single scan. To maintain the specificity of these criteria, it is necessary to determine whether T2/FLAIR visible lesions and the gadolinium enhancement can be attributed t...
Incidental demyelinating inflammatory lesions in asymptomatic patients: a Brazi...
Maia Jr.,Antonio Carlos Martins; Rocha,Antonio José da; Barros,Bernardo Rodi; Tilbery,Charles PeterDespite the definition of specific diagnostic criteria to identify radiologically isolated syndrome (RIS) suggestive of multiple sclerosis, its natural history remains incompletely understood. We retrospectively analyzed a Brazilian cohort of 12 patients to clarify their features and to emphasize the role of imaging predictors in clinical conversion. We demonstrated that, although some individuals did not exhib...