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Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial...

Tavella, Tatyana Almeida; Da Silva, Noeli Soares Melo; Spillman, Natalie; Kayano, Ana Carolina Andrade Vitor; Cassiano, Gustavo Capatti

Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein homeostasis. Mechanisticall...

Date: 2021   |   Origin: Repositório Institucional da UNL
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