4 documents found, page 1 of 1
The potential of multifunctional proteins and peptides for hair protection and ...
Tinoco, Ana Catarina MalheiroO cabelo é um elemento importante na aparência das pessoas, sendo uma das características físicas que podemos controlar e alterar facilmente. No entanto, os procedimentos cosméticos em conjugação com as rotinas diárias e insultos ambientais podem danificar e enfraquecer irreversivelmente as fibras. A indústria cosmética utiliza diferentes formulações contendo proteínas, hidrolisados de proteínas, péptidos ou am...
BSA/ASN/Pol407 nanoparticles for acute lymphoblastic leukemia treatment
Tinoco, Ana Catarina Malheiro; Passos, Marisa Sárria Pereira; Loureiro, Ana Isabel Sá; Parpot, Pier; Espiña, Begoña; Gomes, Andreia CDuring the treatment of acute lymphoblastic leukemia (ALL) with asparaginase (ASN) there is an accumulation of ammonia in the body as result of asparagine hydrolysis. This accumulation known as hyperammonemia is one of the main side-effects of this therapy. To avoid hyperammonemia is urgent to develop new strategies for ammonia retention. Herein is presented the immobilization of ASN into bovine serum albumin/p...
Albumin/asparaginase capsules prepared by ultrasound to retain ammonia
Tinoco, Ana Catarina Malheiro; Ribeiro, Artur J.; Oliveira, César João Santos; Parpot, Pier; Gomes, Andreia C; Cavaco-Paulo, ArturAsparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia. The accumulation of ammonia in the bloodstream leads to hyperammonemia, described as one of the most significant side effects of asparaginase therapy. Therefore, there is a need for asparaginase formulations...
Chemical functionalization in bionanoparticles
Tinoco, Ana Catarina MalheiroAsparaginase is an enzyme that has been extensively used for the treatment of acute lymphoblastic leukemia (ALL) and other lymphoproliferative malignancies. This enzyme catalyzes the hydrolysis of asparagine into aspartic acid and ammonia, resulting in leukemic cancer cells death. One of the side-effects of asparaginase therapy is hyperammonemia that is caused by an abrupt elevation of ammonia levels in plasma ...