5 documents found, page 1 of 1
HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by L...
Couto,Jéssyca F. O.; Simas,Daniel L. R.; Silva,Marcos V. T. e; Barth,Thiago; Pinto,Shaft C.; Tinoco,Luzineide W.; Freire,Denise M. G.The flavonoid rutin presents several pharmacological effects, despite this, its application in the pharmaceutical industry can be significantly limited by its low bioavailability. The development of lipophilic derivatives by esterification of hydroxyl groups with fatty acid chains may be an effective strategy to change their physicochemical properties. This work aims to use high-speed countercurrent chromatogra...
New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
Nascimento,Raimundo R. G.; Pimenta,Antônia T. A.; Lima Neto,Pedro de; C. Junior,José R.; Costa-Lotufo,Letícia V.; Ferreira,Elthon G.Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity ...
Piperamides from Piper ottonoides by NMR and GC-MS Based Mixture Analysis
Wolff,Thiago; Santos,Priscila F. P.; Valente,Ligia M. M.; Magalhães,Alvicler; Tinoco,Luzineide W.; Pereira,Rita C. A.; Guimarães,Elsie F.The species Piper ottonoides Yuncker (Piperaceae), known as “joão-brandim”, is a shrub that occurs in the Brazilian Amazon rainforest. Its roots and leaves are used in traditional medicine as local anesthetic to treat toothache and sore throat. In this study, the structural characterization in mixture of isobutyl amides present in semi-purified fractions from fruits, leaves, stems and roots of P. ottonoides was...
Two new oleanane saponins from Chiococca alba (L.) Hitch.
Borges,Ricardo M.; Tinoco,Luzineide W.; Souza Filho,José D. de; Barbi,Nancy dos Santos; Silva,Antonio Jorge R. daTwo triterpene saponins were isolated from the ethanolic extract of the roots of Chiococca alba (L.) Hitch (Rubiaceae). Their structures were determined by ¹H and 13C 1D and 2D NMR and high resolution electrospray mass spectrometry as 3-O-β-D-glucopyranurosyl-3β-hydroxyolean-12,15-dien-28-oic acid 28-O-α-D-apiofuranosyl (1→3)-[α-D-apiofuranosyl (1→4)]-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl ester (1) and...
Design of inhibitors for nucleoside hydrolase from Leishmania donovani using mo...
França,Tanos C. C.; Rocha,Maria do Ramo M.; Reboredo,Bruno M.; Rennó,Magdalena N.; Tinoco,Luzineide W.; Figueroa-Villar,José D.In this work we propose the first homology model for nucleoside hydrolase from Leishmania donovani, built based on the crystallographic structures of Crithidia fasciculata and Leishmania major nucleoside hydrolases. We used the interaction information from the crystallographic model of the enzyme of C. fasciculata in complex with the inhibitor p-aminophenyliminoribitol, to design two new potential inhibitors, w...