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Antibacterial Layer-by-Layer coatings for medical implants
Escobar, Ane; Muzzio, Nicolas; Moya, Sergio EnriqueThe widespread occurrence of nosocomial infections and the emergence of new bacterial strands calls for the development of antibacterial coatings with localized antibacterial action that are capable of facing the challenges posed by increasing bacterial resistance to antibiotics. The Layer-by-Layer (LbL) technique, based on the alternating assembly of oppositely charged polyelectrolytes, can be applied for the ...
Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration cap...
Faria, Raquel Santos; Lima, Luiza Ianny de; Bonadio, Raphael Severino; Longo, João Paulo Figueiró; Roque, Marjorie Coimbra; Matos Neto, João Nunes deThe main goal of this study is to evaluate the efficacy of the paclitaxel (PTX) drug formulated with a liposomal nanosystem (L-PTX) in a peritoneal carcinomatosis derived from ovarian cancer. In vitro cell viability studies with the human ovarian cancer line A2780 showed a 50% decrease in the inhibitory concentration for L-PTX compared to free PTX. A2780 cells treated with the L-PTX formulation demonstrated a r...