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Exploring Innovations and Key Insights in Healthcare

Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Souza, Júlio C. M.; Tiritan, Maria Elizabeth; Brito, Nuno Vieira

On behalf of the Editorial Team of Scientific Letters, we are pleased to announce the publication of the third issue. The 2024 edition of Scientific Letters presents a diverse array of research that highlights significant advancements in health, dentistry, and clinical treatments.

Date: 2025   |   Origin: Scientific Letters

Enantiomeric profiling of ketamine in street samples for recreational use

Varela, Inês; Milhazes, Nuno; Martins, Daniel; Gonçalves, Virgínia; Tiritan, Maria Elizabeth; Ribeiro, Cláudia

Background: While ketamine (KET) has gained increasing scientific attention for its novel therapeutic applications, there has also been a parallel global rise in its non-medical, recreational use. [1]. Due to its effects on the central nervous system—such as dissociation, perceptual alterations, and its well-known anesthetic properties—KET is frequently used recreationally for its psychoactive effects. [2]. As ...

Date: 2025   |   Origin: Scientific Letters

Microbiome adaptation of aerobic granular sludge allows process resilience duri...

Miranda, Catarina; Maia, Alexandra S.; Tiritan, Maria Elizabeth; Castro, Paula M. L.; Amorim, Catarina L.

Coastal wastewater treatment plants often face multiple stressors (e.g., pharmaceuticals and oscillating seawater levels) simultaneously, and their combined effects on biological treatment systems are still largely underestimated. In this study, an aerobic granular sludge (AGS) reactor was challenged over a four-month period with wastewater that had daily fluctuations in seawater content (7.5 to 22.5 g/L) and o...


Wastewater stressors shape the microbiome of aerobic granular sludge

Miranda, Catarina; Maia, Alexandra S.; Tiritan, Maria Elizabeth; Amorim, Catarina L.; Castro, Paula M. L.

Aerobic granular sludge (AGS) is a revolutionary biological treatment technology, which, due to its competitive advantages, has been increasingly implemented in full-scale wastewater treatment plants (WWTPs). WWTPs are frequently challenged by multiple stressors, including pharmaceuticals and fluctuating salinity, which not only increase the complexity of wastewater but also impair the biological treatment perf...


Exploring the potential of a waste-derived bone char for pharmaceuticals adsorp...

Miranda, Catarina; Scalera, Francesca; Piancastelli, Andreana; Pullar, Robert C.; Tiritan, Maria Elizabeth; Piccirillo, Clara; Castro, Paula M. L.

In this study, the effect of salinity in wastewater on the adsorption capacity of a bone char material prepared through pyrolysis of tuna bones at 1000 °C was investigated for two pharmaceuticals, tramadol (TRA) and venlafaxine (VNF), both contaminants of emerging concern. This is the first time that the adsorption efficiency of a bone char-type material was tested in such conditions. The Tuna Bone Char (TBC) w...


The potential of tuna bone char as a sorbent material for pharmaceuticals remov...

Miranda, Catarina; Piccirillo, Clara; Tiritan, Maria Elizabeth; Castro, Paula M. L.; Amorim, Catarina L.

The extensive consumption of pharmaceuticals combined with the limited removal capacity of wastewater treatment processes result in their continuous accumulation in water bodies which can adversely affect the environment and human health. Thus, efficient strategies to avoid the release of these persistent compounds in the environment are needed. The adsorption-based processes are promising methodologies to redu...


Valorisation of tuna bone waste through its application for the removal of pers...

Piccirillo, Clara; Miranda, Catarina; Scalera, Francesca; Piancastelli, Andreana; Tiritan, Maria Elizabeth; Castro, Paula M. L.; Amorim, Catarina L.

The access to safe and clean water is a critical issue faced by our society. One of the major problems is the presence of contaminants of emerging concern (CECs) in water bodies. CECs include pollutants with poor removal rates in wastewater treatment plants, causing adverse effects on ecosystems and humans. Within CECs, pharmaceuticals received increasing attention due to their continuous release into aquatic e...


Tuna bone char as a waste-derived sorbent for the removal of contaminants of em...

Piccirillo, Clara; Miranda, Catarina; Scalera, Francesca; Piancastelli, Andreana; Tiritan, Maria Elizabeth; Amorim, Catarina L.; Castro, Paula M. L.

Introduction: Today one of the main problems affecting our environment is the presence of Contaminants of Emerging Concern (CECs) in surface waters. CECs are stable compounds that are not degraded by traditional wastewater treatments processes, accumulating in the environment and potentially causing harm. Within CECs, pharmaceuticals are of particular concern, due to their increased consumption, with the new EU...


Aerobic granular sludge system under chiral pharmaceutical exposure: insights o...

Miranda, Catarina; Tiritan, Maria Elizabeth; Castro, Paula M. L.; Amorim, Catarina L.


The potential of tuna bone char as a sorbent material for pharmaceuticals remov...

Miranda, Catarina; Piccirillo, Clara; Tiritan, Maria Elizabeth; Castro, Paula M. L.; Amorim, Catarina L.

The extensive consumption of pharmaceuticals combined with the limited removal capacity of wastewater treatment processes result in their continuous accumulation in water bodies which can adversely affect the environment and human health. Thus, efficient strategies to avoid the release of these persistent compounds in the environment are needed. The adsorption-based processes are promising methodologies to redu...


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