5 documents found, page 1 of 1
Improved Triamcinolone acetonide-eluting contact lenses based on cyclodextrins ...
Marto-Costa, Carolina; Toffoletto, Nadia; Salema-Oom, Madalena; Antunes, Alexandra M. M.; Pinto, Carlos A.; Saraiva, Jorge A.; Silva-Herdade, Ana S.Contact lenses (CLs) constitute an advantageous platform for the topical release of corticosteroids due to their prolonged contact with the eye. However, the lipophilic nature of corticosteroids hampers CLs' ability to release therapeutic amounts. Two approaches to improve loading and release of triamcinolone acetonide (TA) from poly(2-hydroxyethyl methacrylate)-based hydrogels were investigated: adding 2-hydro...
A physiology-based mathematical model to understand drug delivery from contact ...
Toffoletto, Nadia; Saramago, Benilde; Serro, Ana Paula; Chauhan, AnujObjective: Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye after wearing drug-loaded contact lenses, thus opening the possibility of treating the posterior segment without nee...
Drug-loaded hydrogels for intraocular lenses with prophylactic action against p...
Toffoletto, Nadia; Salema-Oom, Madalena; Igea, Soledad Anguiano; Alvarez-Lorenzo, Carmen; Saramago, Benilde; Serro, Ana PaulaPseudophakic cystoid macular edema (PCME), caused by chronic inflammation, is the most common cause of visual impairment in the medium-term after cataract surgery. Therefore, the prophylactic topical administration of combined steroidal and non-steroidal anti-inflammatory drugs is commonly done. Drug-eluting intraocular lenses (IOLs) gained interest as an efficient way to overcome the compliance issues related ...
Asymmetry in drug permeability through the cornea
Toffoletto, Nadia; Chauhan, Anuj; Alvarez-Lorenzo, Carmen; Saramago, Benilde; Serro, Ana PaulaThe permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitute...
Therapeutic ophthalmic lenses : a review
Toffoletto, Nadia; Saramago, Benilde; Serro, Ana PaulaAn increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions f...