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Polycaprolactone-based fibrous scaffolds reinforced with cellulose nanocrystals...

Rocha, Joana M.; Sousa, Rui Pedro Carvalho Lima; Sousa, Diogo; Tohidi, Shafagh Dinparast; Ribeiro, Artur; Fangueiro, Raúl; Ferreira, Diana P.

Anterior cruciate ligament (ACL) injuries pose significant challenges, driving the need for innovative repair strategies. Tissue engineering (TE) has emerged as a promising field for ACL injuries. Wet spinning is a filament production technique that enables precise control over filament alignment, diameter, and porosity, making it suitable for developing new scaffolds for ACL injuries. This study develops fibro...


Fast, multiple-use optical biosensor for point-of-care glucose detection with m...

Braz, Joana Filipa Barros; Dencheva, Nadya Vasileva; Tohidi, Shafagh Dinparast; Denchev, Z.

Non-invasive glucose determination provides major advantages in health monitoring and protection. It enables widespread point-of-care testing, which is affordable, sensitive, specific, rapid and equipment-free. This work reports on the development and analytical performance of a colorimetric biosensor in detecting glucose in human urine. Highly porous polyamide microparticles were synthesized as the support for...


Smart-phone read optical biosensor for glucose determination using polymer-assi...

Braz, Joana Filipa Barros; Dencheva, Nadya Vasileva; Tohidi, Shafagh Dinparast; Denchev, Z.

Diabetes mellitus, commonly known as diabetes, is an urgent global health crisis. These motivated the widespread development of non-invasive point-of-care (POCT) technologies for continuous, real-time glucose monitoring in biofluids such as urine. The sensitive colorimetric method is the easiest and fastest method that produces a distinctive color change to the target analyte and is observed by the naked eye, e...


Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced...

Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Fertuzinhos, Aureliano Costa; Tohidi, Shafagh Dinparast; Reis, Salette

Infection is a major issue in chronic wound care. Different dressings have been developed to prevent microbial propagation, but an effective, all-in-one (cytocompatible, antimicrobial and promoter of healing) solution is still to be uncovered. In this research, polyvinyl alcohol (PVA) nanofibrous mats reinforced with cellulose nanocrystal (CNC), at 10 and 20% v/v ratios, were produced by electrospinning, crossl...


Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose ac...

Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Tohidi, Shafagh Dinparast; Reis, Salette; Amorim, M. T. Pessoa de

In this research, we propose to engineer a nanostructured mat that can simultaneously kill bacteria and promote an environment conducive to healing for prospective wound care. Polyvinyl alcohol (PVA) and cellulose acetate (CA) were combined at different polymer ratios (100/0, 90/10, 80/20% v/v), electrospun and crosslinked with glutaraldehyde vapor. Crosslinked fibers increased in diameter (from 194 to 278 nm),...


Antimicrobial evaluation of the synergisms of Tiger 17 and pexiganan peptides w...

Teixeira, Marta Albertina Fernandes; Antunes, Joana Isabel Costa; Ferreira, Diana P.; Tohidi, Shafagh Dinparast; Amorim, M. T. Pessoa de

[Excerpt] The incidence of chronic wounds (CW) is growing at an accelerated rate around the world. To address this problem, new wound dressings functionalized with active biomolecules are being engineered to manage and treat CW [1]. The introduction of peptides, such as pexiganan and tiger 17, has already been established as a viable solution within dressing formulations due to the emergence of bacterial strain...


Ceramic sonotrodes for light alloy melt treatment

Puga, Hélder; Tohidi, Shafagh Dinparast; Carneiro, V. H.; Meireles, José; Prokic, M.

Alloy melt treatment by ultrasonic vibration is a physical processing technique that has been gathering the support of the scientific community. The use of metallic sonotrodes for this purpose has been proven very efficient; however, it promotes melt inclusion by sonotrode erosion. Such an issue is being addressed by the use of ceramic sonotrodes in low-amplitude resonance. Given that these novel sonotrodes gen...


Development and characterization of single polymer composites prepared by compr...

Tohidi, Shafagh Dinparast; Dencheva, Nadya Vasileva; Denchev, Z.; Rocha, Ana Maria; Engesser, Bernhard

In the present study, novel polyamide 6 based woven single polymer composites (WSPC) were developed by powder-coating of woven textile structures with polyamide 6 empty microcapsules (EMC) and subsequent compression molding. To synthesize EMC, activated anionic ring-opening polymerization of ε-caprolactam by solution/precipitation was applied. Stitched plain fabrics that are promising novel class of woven fabri...


Effect of hybrid ultrasonic and mechanical stirring on the distribution of m-Si...

Grilo, J.; Puga, Hélder; Carneiro, V. H.; Tohidi, Shafagh Dinparast; Barbosa, Flávia Vieira; Teixeira, J. Carlos

The present study details the micro-scale silicon carbide particle (m-SiCp) homogeneous distribution in an A356 alloy through hybrid ultrasonic-stirring melt treatment under different operation conditions. Ultrasonically excited fluids were studied by particle image velocimetry to estimate the efficiency of the acoustic streaming in different distances to the sonotrode. Distinct particle approaches to introduce...


Influence of transcrystalline layer on finite element mesoscale modeling of pol...

Tohidi, Shafagh Dinparast; Rocha, Ana Maria A. C.; Dourado, N.; Rezazadeh, Mohammadali; Quyen, Nguyen Trong; Zille, Andrea; Hesseler, Stefan

This study presents a novel approach for finite element modeling of the elastic behavior of a plain-woven reinforced single polymer laminate composites (WSPC) based on polyamide 6 (PA6). These composites are produced via compression molding of PA6 woven textile structures that are powder-coated by anionic PA6 microparticles. Morphological and structural analysis complemented by electron microscopy, image proces...


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