2 documents found, page 1 of 1
Genetic diversity of human immunodeficiency virus-1 isolates in Paraná, Brazil
Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Rossi,Silvia Gomes de; Brindeiro,Rodrigo; Queiroz-Telles,Flávio deOBJECTIVE: Because epidemiological data on circulating HIV subtypes among HIV-positive patients in the state of Paraná were not known until now, the aims of this study were to describe the genetic diversity profile of HIV-1 in treated patients in Paraná, Brazil, and report the differences in protease (PR) and reverse transcriptase (RT) mutations in HIV-1 subtypes. PATIENTS AND METHODS: A cross-sectional study w...
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy i...
Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Romagnoli,Luiza; Marcinko,Gustavo; Cunha,Clovis Arns da; Souza,Margely Nunes deAntiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (dr...