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Quality of bevacizumab (Avastin®) repacked in single-use glass vials for intrav...
Sugimoto,Michelle A. A.; Toledo,Vicente de Paulo Coelho Peixoto de; Cunha,Mariem Rodrigues Ribeiro; Carregal,Virginia M.; Jorge,Rodrigo; Leão,PedroABSTRACT Purpose: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its division into single-use vials to meet the low volume and low-cost doses necessary for intraocular administration. How...
Comparison of cytokine levels and metabolic parameters of stored platelet conce...
Costa,Evaldo José; Guimarães,Tânia Mara Pinto Dabés; Almeida,Nathalia Correia de; Toledo,Vicente de Paulo Coelho Peixoto deBACKGROUND: Prolonged storage of platelets could improve availability and logistical management and decrease wastage. Immunobiochemical methods can be used to guarantee the quality of platelets after prolonged storage. OBJECTIVE: The aim of this study was to compare storage-related changes in buffy coat-derived platelet concentrations versus platelet-rich plasma. METHODS: Units of whole blood were drawn using a...
Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed proma...
Mayrink,Wilson; Santos,Gilmara Cristina dos; Toledo,Vicente de Paulo Coelho Peixoto de; Guimarães,Tânia Mara Pinto DabésAntigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences we...