78 documents found, page 1 of 8
Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cispla...
Camacho, Cláudia; Maciel, Dina; Tomás, Helena; Rodrigues, JoãoCisplatin (cis-diamminedichloroplatinum(II)) is a potent chemotherapeutic agent com monly used to treat cancer. However, its use also leads to serious side effects, such as nephrotoxicity, ototoxicity, and cardiotoxicity, which limit the dose that can be safely administered to patients. To minimize these problems, dendrimers may be used as carriers for cisplatin through the coordination of their terminal functi...
Global Women’s Breakfast (GWB): #UnidaspelaQuímica
Aguiar-Ricardo, Ana; Alves, Arminda; Antunes, M. Cristina; Batalha, Filipa; Oliveira Brett, Ana Maria; Camões, Filomena; Cardoso, Ana L.Global Women’s Breakfast (GWB): #BoundbyChemistry. Global Women’s Breakfast is an initiative of the International Union of Pure and Applied Chemistry, aiming to give women scientists, from all over the world, the opportunity to know each other, communicating virtually and sharing their experiences. Many countries joined this initiative and Portugal was not an exception, with its participation already at the fir...
Self‐assembly of cholesterol‐Doxorubicin and TPGS into Prodrug‐based nanopartic...
Olim, Filipe; Neves, Ana Rute; Vieira, Mariana; Tomás, Helena; Sheng, RuilongDeveloping new easy-to-prepare functional drug delivery nanosystems with good storage stability, low hemotoxicity, as well as controllable drug delivery property, has attracted great attention in recent years. In this work, a cholesterol-based prodrug nanodelivery system is prepared by self-assembly of cholesterol-doxorubicin prodrug conjugates (Chol-Dox) and tocopherol polyethylene glycol succinate (TPGS) usin...
Cytocompatible cellulose nanofibers from invasive plant species Agave americana...
Evdokimova, Olga L.; Alves, Carla S.; Krsmanović Whiffen, Radenka M.; Ortega, Zaida; Tomás, Helena; Rodrigues, João: In this study, the fibers of invasive species Agave americana L. and Ricinus communis L. were successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose nanofibers. Cellulose nanofibers were obtained by two methods, based on either alkaline or acid hydrolysis. The morphology, chemical composition, and crystallinity of the obtained materials were characterize...
Polyester Dendrimers Based on Bis-MPA for Doxorubicin Delivery
Gonçalves, Mara; Kairys, Visvaldas; Rodrigues, João; Tomás, HelenaAlthough doxorubicin (DOX) is one of the most used chemotherapeutic drugs due to its efficacy against a wide group of cancer types, it presents severe side effects. As such, intensive research is being carried out to find new nanoscale systems that can help to overcome this problem. Polyester dendrimers based on the monomer 2,2-bis- (hydroxymethyl)propionic acid (bis-MPA) are very promising systems for biomedic...
Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed go...
Mignani, Serge; Shi, Xiangyang; Ceña, Valentin; Rodrigues, João; Tomás, Helena; Majoral, Jean-PierreNanomedicine represents a very significant contribution in current cancer treatment; in addition to surgical intervention, radiation and chemotherapeutic agents that unfortunately also kill healthy cells, inducing highly deleterious and often life-threatening side effects in the patient. Of the numerous nanoparticles used against cancer, gold nanoparticles had been developed for therapeutic applications. Inter ...
Cyclotriphosphazene-based derivatives for antibacterial Applications: an update...
Su, Xiqi; Wang, Le; Xie, JingHua; Liu, XiaoHui; Tomás, HelenaAs a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for the synthesis of varieties of derivatives, including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic, flame retardant and bio logical activities. Some metal-binding HCCP derivatives have shown antibacterial activities as free ligands and metal complexes. These derivatives can ...
Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug system...
Wang, Zhao; Olim, Filipe; Sun, Jingjing; Neves, Ana Rute; Mendes, Fátima; Tomás, Helena; Sheng, RuilongUtilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/red...
Use of half-generation PAMAM dendrimers (G0. 5–G3. 5) with carboxylate end-grou...
Camacho, Cláudia; Tomás, Helena; Rodrigues, JoãoThe DACHPtCl2 compound (trans-(R,R)-1,2-diaminocyclohexanedichloroplatinum(II)) is a potent anticancer drug with a broad spectrum of activity and is less toxic than oxaliplatin (trans-l-diaminocyclohexane oxalate platinum II), with which it shares the active metal fragment DACHPt. Nevertheless, due to poor water solubility, its use as a chemotherapeutic drug is limited. Here, DACHPtCl2 was conjugated, in a bide...
Engineered fluorescent carbon dots and G4-G6 PAMAM dendrimer nanohybrids for bi...
Martins, Ivo; Tomás, Helena; Lahoz, Fernando; Rodrigues, JoãoABSTRACT: Carbon dots (CDs) and G4-G6 (polyamidoamine)- PAMAM-NH2 dendrimers were self-assembled to produce CDs@ PAMAM nanohybrids for transfection and bioimaging purposes. CDs were synthesized by the hydrothermal method, using ascorbic acid as a starting precursor and characterized by transmission electron microscopy, UV−Vis, and fluorescence (in solution and solid-state) techniques. CDs were electrostatically...