7 documents found, page 1 of 1
Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) wit...
Sousa, Felipe Domingos de; Vasconselos, Pedrinha Diógenes; Silva, Ayrles Fernanda Brandão da; Mota, Erika Freitas; Tomé, Adriana da RochaPlant lectins are carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions. Here, we have extracted, purified and part-characterized the bioactivity of Jacalin, Frutalin, DAL and PNA, before evaluating their potential for wound healing in cultured human skin fibroblasts. Only Frutalin stimulated fibroblast migration in vit...
Counteracting effects on free radicals and histological alterations induced by ...
Araújo, Éverton José Ferreira de; Oliveira, Guilherme Antônio Lopes de; Sousa, Lívia Queiroz de; Bolzani, Vanderlan da Silva; Cavalheiro, Alberto JoséCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. ...
Diagnóstico de doença prostática canina – características histopatológicas da p...
Gadelha, Carla Renata Figueiredo; Vicente, Wilter Ricardo Russiano; Viana, Daniel de Araújo; Campos, Ana Claudia Nascimento; Mendonça, Ingrid Barbosa deSixty seven male and intact dogs were grouped according to the age in three groups: 1 - 3 years (group), 4 - 6 years (group B) and above of seven years (group C). Ten animals with alterations in parenchyma prostate evaluated by ultrasonography had been grouped separately (group D) independently of the age. Part of the animals was submitted to the transabdominal ultrasonography and biopsy (25 animals) and anothe...
Ethanol-induced gastric injury : microscopic analysis of the protective effect ...
Abdon, Ana Paula Vasconcellos; Vasconcelos, Renata Prado; Castro, Carolina Araújo; Guedes, Marjorie Moreira; Tomé, Adriana da RochaObtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanolinduced gastric injury. The gastroprotective effect of frutalina was evaluated ...
The effect of natural and organophilic palygorskite on skin wound healing in rats
Silva, Mirna Luciano de Gois da; Fortes, Amanda Campos; Tomé, Adriana da Rocha; Silva Filho, Edson Cavalcanti da; Freitas, Rivelilson Mendes deIn view of growing interest in natural treatments, clays would appear to be a good alternative for speeding up the healing process during the treatment of wounds. Of the various clays, palygorskite, a clay from the Brazilian State of Piauí, composed of silicon and aluminum, has shown itself to be pharmaceutically useful as a healing agent. The aim of this article is to evaluate the effect on the healing of woun...
Estudo dos efeitos da inibição crônica do óxido nítrico na reprodução de ratos ...
Tomé, Adriana da RochaNitric Oxide (NO) derived from L-arginine by the nitric oxide synthase (NOS) which is expressed by various isoforms, is considered to be na important messenger molecule in several organ systems including the male genital tract. This study analysed the possible effects of L-NAME (NG-nitro-L-arginine methyl ester), a nonselective NOS inhibitor on testicilar descent; cholinergic stimulation-induced seminal emissio...
Neuroprotective actions of vitamin C in rat striatum after pilocarpine-induced ...
Freitas, Rivelilson Mendes de; Tomé, Adriana da RochaBACKGROUND: Seizures may produce neuronal damage in several areas and especially in limbic structures. OBJECTIVES: This study aimed to evaluate the neuroprotective effects of vitamin C in the histopathological changes observed in rat striatum after seizures. MATERIAL AND METHODS: Healthy Wistar rats were divided into four groups. The first group was treated with 0.9% saline (control group) and the second one wi...