10 documents found, page 1 of 1
Malignant otitis externa: experience at a tertiary center
Caetano, Mariana; Rosa, Cláudia; Correia, Mariana; Levy, João; Eça, Tiago; Carvalho, Tomás; Tomé, Diogo; Luís, LeonelObjective: This study seeks to report the experience of a tertiary medical institution in managing MOE. Materials and Methods: A retrospective analysis of MOE cases admitted to our tertiary hospital from January 2018 to December 2023 was conducted. Results: Six patients, with a median age of 81.7 years, were included. Pseudomonas aeruginosa was the most isolated organism. CT scans, conducted for all patients, r...
Neuroprotection by mitochondrial NAD against glutamate-induced excitotoxicity
Paiva, Bruna S.; Neves, Diogo; Tomé, Diogo; Costa, Filipa J.; Bruno, Inês C.; Trigo, Diogo; Silva, Raquel M.; Almeida, Ramiro D.Excitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs). Nicotinamide adenine dinucleotide (NAD) depletion is an early event following excitotoxicity in many in vitro and in vivo excitotoxic-related models and contributes to the...
Relatório de Estágio Curricular – Canal N (Bragança)
Tomé, DiogoO presente relatório descreve todo o percurso académico durante o período de estágio curricular no CanalN, para a conclusão de estudos no curso de Comunicação Multimédia na Escola de Educação, Comunicação e Desporto do Instituto Politécnico da Guarda. O objetivo é esclarecer todo o tipo de atividades desempenhadas durante o mesmo, no respetivo período entre 11 de julho e 19 de setembro no CanalN, Mirandela. A p...
Fibroblast growth factor signaling in axons: from development to disease
Tomé, Diogo; Dias, Marta S.; Correia, Joana; Almeida, Ramiro D.The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due ...
Isolated sphenoid sinus lesions: A tertiary hospital experience
Caetano, Mariana; Rosa, Cláudia; Oliveira, Mafalda; Oliveira, Vítor; Tomé, Diogo; Luís, LeonelAt the request of the authors, we inform that in the article "Isolated sphenoid sinus lesions: A tertiary hospital experience", published in the Portuguese Journal of Otorhinolaryngology - Head and Neck Surgery, volume 60, No2 - December 2022, two authors were not included in the authorship of the article by mistake, so the correction is here. Isolated sphenoid sinus lesions: A tertiary hospital experience Auth...
Isolated Sphenoid Sinus lesions: a Tertiary Hospital Experience
Caetano, Mariana; Oliveira, Vítor; Tomé, Diogo; Luís, LeonelObjective: To review and report isolated sphenoid sinus diseases from a tertiary hospital, with special attention to the patients' presenting symptoms, diagnosis, and clinical outcomes. Study Design, Material and Methods:Retrospective chart review performed on patients diagnosed with isolated sphenoid sinus disease, undergoing endoscopic sinus surgery between January 2017 and December 2021. Results: 19 patients...
Complex sleep-disordered breathing after vagus nerve stimulation: broadening th...
Oliveira Santos, Miguel; Bentes, Carla; Teodoro, Tiago; Moreira, Susana; Marques, Marta; Tomé, Diogo; Peralta, AnaTwo young males with refractory epilepsy of unknown aetiology were referred for vagus nerve stimulation (VNS). Sleep disturbances emerged following VNS parameter changes. In Patient 1, video-polysomnogram (PSG) disclosed snoring and catathrenia in non-REM sleep. Central apnoea also occurred, but more rarely. In Patient 2, video-PSG showed mixed apnoea with desaturation and episodes of stridor followed by a cata...
Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons
Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; Jeon, Noo Li; Cancedda, LauraRibosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly reduced or even absent. The mechanism that elicits this removal is currently unknown. Here, we demonstrate that sy...
Severity predictors in severe idiopathic epistaxis: A retrospective review of h...
Tomé, Diogo; Canas Marques, Marta; Rocha Pereira, Paulo; Simão, Marco; Dias, ÓscarIntroduction: Studies have shown conflicting results about the risk factors of idiopathic epistaxis. The aim of this study is to identify predictors of severity in patients hospitalized with idiopathic epistaxis. Study design: Observational, analytical, case-control, retrospective study. Material and Methods: Data of 134 patients admitted over a period of 10 years, were collected. The sample was divided in two ...
A fluorescence based sensor assay that monitors general protein aggregation in ...
Pereira, Marisa; Tomé, Diogo; Domingues, Ana S.; Varanda, Ana S.; Paulo, Cristiana; Santos, Manuel A. S.; Soares, Ana R.Protein conformational disorders are characterized by disruption of protein folding and toxic accumulation of protein aggregates. Here we describe a sensitive and simple method to follow and monitor general protein aggregation in human cells. Heat shock protein 27 (HSP27) is an oligomeric small heat shock protein that binds and keeps unfolded proteins in a folding competent state. This high specificity of HSP27...