5 documents found, page 1 of 1
Energy restriction, exercise and atorvastatin treatment improve endothelial dys...
Rocha, B; Rodrigues, AR; Tomada, I; Martins, MJ; Guimarães, J; Gouveia, AM; Almeida, H; Neves, DBackground: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
The influence of metabolic profile of obese men on the severity of erectile dys...
Moura, A; Tomada, I; Tomada, NObjective: To determine the prevalence of erectile dysfunction (ED) in metabolically healthy obese (MHO) individuals, and to compare ED severity and hypogonadism prevalence in MHO, metabolically unhealthy obese (MUO) and metabolically healthy non-obese individuals.Material and methods: ED patients (n=460) were evaluated by standardized protocol, that included clinical evaluation, abridged 5-item version of the ...
Endothelial function in patients with metabolic syndrome and erectile dysfuncti...
Tomada, N; Tomada, I; Botelho, F; Pacheco-Figueiredo, L; Lopes, T; Negrão, R; Pestana, M; Cruz, FErectile dysfunction (ED) is a highly prevalent disease whose aetiology is mostly vasculogenic. It is nowadays considered a marker of future cardiovascular events reflecting the underlying endothelial dysfunction, the common link with the metabolic syndrome (MetS). The recent association between MetS, endothelial dysfunction and peripheral artery disease, but not with coronary artery disease (CAD), suggests tha...
Metabolic syndrome and erectile dysfunction: Assessing the clinical and hemodyn...
Pacheco-Figueiredo, L; Neves, E; Coutinho, P; Botelho, F; Tomada, I; Tomada, NObjetivos Calcular a prevalência de fatores de risco cardiovascular, incluindo a síndrome metabólica (SM), numa série de doentes portugueses com disfunção erétil (DE) e quantificar o impacto individual e agregado dos mesmos, nos parâmetros hemodinâmicos e no grau de severidade reportada. Material e métodos Estudo de uma série de 408 doentes com DE seguidos em consulta de Urologia, no período 2008-2010. A SM foi...
Real-Time PCR Study of Ang1, Ang2, Tie-2, VEGF, and KDR Expression in Human Ere...
Figueiredo, A; Cordeiro, AL; Tomada, N; Tomada, I; Rodrigues, A; Gouveia, Alexandra; Neves, DIntroduction. Aging is a recognized risk factor for erectile dysfunction (ED), contributing independently to vascular damage of penile tissue. Vascular maintenance depends on angiogenic balance in tissues. Vascular endothelial growth factor (VEGF) is a modulator of endothelial cells functions, after engagement to specific receptor kinase domain region (KDR). Other factors, such as angiopoietins, cross talk wit...