2 documents found, page 1 of 1
Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 y...
Fernandes, Camila; Gonçalves, Heitor Sá; Cabral, Paula Brito e; Pinto, Helena Câmara; Pinto, Maria Isabel Moraes; Câmara, Lilia Maria CarneiroBackground: Leprosy is a chronic disease, caused by Mycobacterium leprae, which poses a serious public health problem worldwide. Its high incidence in people under 15 years old in Ceara´ state, Brazil, reflects the difficulty of its control. The spectrum of clinical manifestations is associated with the immune response developed, with the Th1 and Th2 responses being related to the paucibacillary and multibacill...
Anti-PGL1 salivary IgA/IgM, serum IgG/IgM, and nasal Mycobacterium leprae DNA i...
Cabral, Paula Brito e; Cunha Júnior, José Evandro; Macedo, Alexandre Casimiro de; Gondim, Ana Paula Soares; Pinto, Maria Isabel MoraesObjectives: Leprosy household contacts represent a group at high risk of developing the disease. The aim of this study was to detect Mycobacterium leprae subclinical infection in this group through serological and molecular parameters. Methods: Serum anti-PGL1 IgG/IgM and salivary anti-PGL1 IgA/IgM was investigated using an ELISA, and nasal carriage of M. leprae DNA was detected by PCR, in leprosy household con...