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Variation in follow-up for children born very preterm in Europe

Seppänen, AV; Barros, H; Draper, ES; Petrou, S; Andronis, L; Kim, S; Maier, RF; Pedersen, P; Gadzinowski, J; Pierrat, V; Sarrechia, I; Lebeer, J

Background Children born very preterm (<32 weeks of gestation) face high risks of neurodevelopmental and health difficulties compared with children born at term. Follow-up after discharge from the neonatal intensive care unit is essential to ensure early detection and intervention, but data on policy approaches are sparse. Methods We investigated the characteristics of follow-up policy and programmes in 11 Euro...


Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Follow-up after very preterm birth in Europe

Seppänen, AV; Draper, ES; Petrou, S; Barros, H; Andronis, L; Kim, SW; Maier, RF; Pedersen, P; Gadzinowski, J; Lebeer, J; Ådén, U; Toome, L

Follow-up programmes aim to detect neurodevelopmental and health problems and enable early interventions for children born very preterm (<32 weeks of gestational age (GA)). Although the importance of postdischarge follow-up is widely acknowledged, recommendations differ regarding eligibility criteria, frequency, duration and content, especially for follow-up beyond early childhood.1–3 We used data from a Europe...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Managing mother’s own milk for very preterm infants in neonatal units in 11 Eur...

Rodrigues, C; Zeitlin, J; Wilson, E; Toome, L; Cuttini, M; Maier, RF; Pierrat, V; Barros, H; EPICE Research Group

Feeding with human milk has been recognised as an essential component of newborn care and is especially important for infants born very preterm (VPT, below 32 weeks of gestation) who face higher risks of adverse outcomes. WHO recommends that infants who cannot be fed mother's own milk (MOM) should receive donor human milk. Direct feeding at the breast takes time to establish after VPT birth and procedures are r...


Parents' ratings of post-discharge healthcare for their children born very pret...

Seppänen, AV; Sauvegrain, P; Draper, ES; Toome, L; El Rafei, R; Petrou, S; Barros, H; Zimmermann, LJI; Cuttini, M; Zeitlin, J; SHIPS Research Group

Background Follow-up of very preterm infants is essential for reducing risks of health and developmental problems and relies on parental engagement. We investigated parents’ perceptions of post-discharge healthcare for their children born very preterm in a European multi-country cohort study. Methods Data come from a 5-year follow-up of an area-based cohort of births <32 weeks’ gestation in 19 regions from 11 E...


Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very prete...

Zeitlin, J; Maier, RF; Cuttini, M; Aden, U; Boerch, K; Gadzinowski, J; Jarreau, PH; Lebeer, J; Norman, M; Pedersen, P; Petrou, S; Pfeil, JM; Toome, L

The EPICE cohort is a geographically defined study of still-births and live births from 22 þ 0 to 31 þ 6 weeks of gestation in 19 European regions (Fig. 1). Regions were selected with respect to geographic and organizational diversity and feasibility, meaning they had systems for collecting population data on VPT babies that could be modified to integrate the study protocol. In France, the EPICE study includes ...


Specialist health care services use in a European cohort of infants born very p...

Seppänen, AV; Bodeau-Livinec, F; Boyle, EM; Edstedt-Bonamy, AK; Cuttini, M; Toome, L; Maier, RF; Cloet, E; Koopman-Esseboom, C; Pedersen, P

Aim Children born very preterm require additional specialist care because of the health and developmental risks associated with preterm birth, but information on their health service use is sparse. We sought to describe the use of specialist services by children born very preterm in Europe. Method We analysed data from the multi-regional, population-based Effective Perinatal Intensive Care in Europe (EPICE) coh...


Room for improvement in breast milk feeding after very preterm birth in Europe:...

Wilson, E; Bonamy, A; Bonet, M; Toome, L; Rodrigues, C; Howell, E; Cuttini, M; Zeitlin, J; Barros, H; Rodrigues, T

Breast milk feeding (BMF) is associated with lower neonatal morbidity in the very preterm infant (<32 weeks gestation) and breastfeeding is beneficial for maternal health. Previous studies show large variations in BMF after very preterm birth and recognize the need for targeted breastfeeding support in the neonatal intensive care units (NICU). In a European collaboration project about evidence‐based practices a...


Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals...

Norman, M; Piedvache, A; Børch, K; Huusom, LD; Bonamy, AK; Howell, EA; Jarreau, PH; Maier, RF; Pryds, O; Toome, L; Varendi, H; Weber, T; Wilson, E

Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective:To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perin...


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