4 documents found, page 1 of 1
Protecting the most vulnerable: Tuberculosis in immunocompromised individuals
Torrado, E; Van Crevel, R; Afonso, AR; Amorim, D; Duarte, RThe interaction of Mycobacterium tuberculosis with components of the innate and acquired immune system has significant implications for the clinical outcome of infection (clearance, latency or progression to active disease). Thus, the risk of progressing from LTBI to active TB is greater in some populations. Understanding which populations are at increased risk of TBI and of TB disease is essential to understan...
A nonribosomal peptide synthase gene driving virulence in Mycobacterium tubercu...
Bhatt, K; Machado, H; Osório, N; Sousa, J; Cardoso, F; Magalhães, C; Chen, B; Chen, M; Kim, J; Singh, A; Ferreira, C; Castro, A; Torrado, E; Jacobs, WNonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...
L-threonine supplementation during colitis onset delays disease recovery
Gaifem, J; Gonçalves, L; Dinis-Oliveira, R; Cunha, C; Carvalho, A; Torrado, E; Rodrigues, F; Saraiva, M; Castro, A; Silvestre, RDietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability. Several nutrients have already been associated with a protective phenotype. Yet, there is a lack of knowledge toward the most promising ones as well as the most ad...
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of...
Carvalho, A; Cunha, C; Almeida, AJ; Osório, NS; Saraiva, M; Teixeira-Coelho, M; Pedreiro, S; Torrado, E; Domingues, N; Gomes-Alves, AG; Marques, ANon-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is b...