5 documents found, page 1 of 1
Subnational mapping of HIV incidence and mortality among individuals aged 15–49...
Sartorius, B; VanderHeide, JD; Yang, M; Goosmann, EA; Hon, J; Haeuser, E; Cork, MA; Perkins, S; Jahagirdar, D; Schaeffer, LE; Serfes, AL; LeGrand, KEBackground. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we devel...
Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the...
Spencer, AP; Torrado, M; Custódio, B; Silva-Reis, SC; Santos, S; Leiro, V; Pêgo, APCentral nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed...
Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro ...
Moreno, PMD; Rodrigues, T; Torrado, M; Amaral, IF; Pêgo, APBiomaterials-based hydrogels are attractive drug-eluting vehicles in the context of RNA therapeutics, such as those utilizing antisense oligonucleotide or RNA interference based drugs, as they can potentially reduce systemic toxicity and enhance in vivo efficacy by increasing in situ concentrations. Here we describe the preparation of antisense oligonucleotide-loaded fibrin hydrogels exploring their application...
PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...
Santos, SD; Xavier, M; Leite, D; Moreira, D; Custódio, B; Torrado, M; Castro, R; Leiro, V; Rodrigues, J; Tomás, H; Pêgo, APDrug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...
Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in S...
Moreno, PM; Ferreira, AR; Salvador, D; Rodrigues, MT; Torrado, M; Carvalho, ED; Tedebark, U; Sousa, MM; Amaral, IF; Wengel, J; Pêgo, APAfter spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site, through the contribution of multiple factors. The potential of antisense oligonucleotides (AONs) to modify gene expression at different levels, allowing the regulation of cell survival and cell function, together with the availability of chemically modified...