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Factors Associated with Mortality in Nosocomial Lower Respiratory Tract Infections

Reyes, Luis Felipe; Torres, Antoni; Olivella-Gomez, Juan; Ibáñez-Prada, Elsa D.; Nseir, Saad; Ranzani, Otavio T.; Povoa, Pedro; Diaz, Emilio

Funding Information: This research was funded by the IReL Consortium. European Respiratory Society Clinical Research Collaboration (Prof Ignacio Martin-Loeches) for The European Network for ICU-Related Respiratory Infections (ENIRRIs) and Universidad de La Sabana [MED-244-2018]. Publisher Copyright: © 2025 by the authors.; Background: Nosocomial lower respiratory tract infections (nLRTIs) are associated with un...


Nosocomial lower respiratory tract infections in patients with immunosuppression

Reyes, Luis Felipe; Sanabria-Herrera, Natalia; Nseir, Saad; Ranzani, Otavio T.; Povoa, Pedro; Diaz, Emilio; Schultz, Marcus J.; Rodríguez, Alejandro

Funding Information: This work was supported by the IReL Consortium. European Respiratory Society Clinical Research Collaboration (Prof. Ignacio Martin-Loeches) for The European Network for ICU-Related Respiratory Infections (ENIRRIs), Universidad de La Sabana, Chia, Colombia [Grant Number: MED-244-2018]\u00A0and Clinica Universidad de La Sabana, Chia, Colombia. Publisher Copyright: © The Author(s) 2025.; Backg...


How to use biomarkers of infection or sepsis at the bedside

Povoa, Pedro; Coelho, Luís; Dal-Pizzol, Felipe; Ferrer, Ricard; Huttner, Angela; Conway Morris, Andrew; Nobre, Vandack; Ramirez, Paula; Rouze, Anahita

Funding This work received an unrestricted grant from GSK Portugal and was supported by Sociedade Portuguesa de Ginecologia (SPG).; Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response or response to treatment and/or aid clinicians to prognosti...


Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventil...

Ceccato, Adrian; Camprubí-Rimblas, Marta; Bos, Lieuwe D.J.; Povoa, Pedro; Martin-Loeches, Ignacio; Forné, Carles; Areny-Balagueró, Aina

Funding Information: This study was partially supported by Abionic, CIBERES, and Research and Innovation Institute Parc Tauli (I3PT). A.C. acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087). The funding sources had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation,...


Relationship between corticosteroid use and incidence of ventilator-associated ...

Saura, Ouriel; Rouzé, Anahita; Martin-Loeches, Ignacio; Povoa, Pedro; Kreitmann, Louis; Torres, Antoni; Metzelard, Matthieu; Du Cheyron, Damien

Funding This study was supported in part by a grant from the French government through the « Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). Prof. Ignacio Martin-Loeches has been supported by SFI (Science Foundation Ireland), Grant number 20/COV/0038. The funders of the study had no role in the study design, data collection, analysis or interpr...


COVID-19 symptoms at hospital admission vary with age and sex

Abdukahil, Sheryl Ann; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adriao, Diana; Ainscough, Kate

Funding This work was supported by the Department for International Development and Wellcome Trust [215091/Z/18/Z]; the Bill and Melinda Gates Foundation [OPP1209135]. Country-specifc support was provided by the Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity [OV2170359]; the Health Research Board Ireland [CTN Award 2014-012]; National Institute for Health Research (NIHR) [...


Relationship between ventilator-associated pneumonia and mortality in COVID-19 ...

Nseir, Saad; Martin-Loeches, Ignacio; Povoa, Pedro; Metzelard, Matthieu; Du Cheyron, Damien; Lambiotte, Fabien; Tamion, Fabienne; Labruyere, Marie

Funding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication.; BACKGROUND: Patients with SARS-CoV-2 ...


Correction to

Nseir, Saad; Martin-Loeches, Ignacio; Povoa, Pedro; Metzelard, Matthieu; Du Cheyron, Damien; Lambiotte, Fabien; Tamion, Fabienne; Labruyere, Marie

Following publication of the original article [1], the authors identified an error in the Abstract and Results section. The correct numbers and text are given hereafter. Abstract VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 group (adjusted HR 1.65 (95% CI 1.11–2.46), p = 0.013), but not in influenza (1.74 (0.99–3.06), p = 0.052), or no viral infection groups (1.13 (0.68–1...


Soluble urokinase plasminogen activator receptor for the prediction of ventilat...

Van Oort, Pouline M.; Bos, Lieuwe D.; Povoa, Pedro; Ramirez, Paula; Torres, Antoni; Artigas, Antonio; Schultz, Marcus J.; Martin-Loeches, Ignacio

Introduction: Diagnosing ventilator-associated pneumonia (VAP) remains challenging. Soluble urokinase plasminogen activator receptor (suPAR) has prognostic value in critically ill patients with systemic infection. We hypothesised that plasma suPAR levels accurately predict development of VAP. Methods: This observational, multicentre, prospective cohort study compared patients at risk for VAP with a control grou...


Biomarkers in community-acquired pneumonia

Ranzani, Otavio Tavares; Coelho, Luis; Torres, Antoni


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