58 documents found, page 1 of 6
The protocol for a patient-driven online prospective European observational coh...
Grohmann, Teresa; Mtenga, Timeo; Kerr, David; Barrett, Joe; Gray, Nathanael; Bertheussen, Heidi; Cañete, Juan D.; de Vlam, Kurt; de Wit, MaartenBackground: Up to one-third of people living with psoriasis develop psoriatic arthritis (PsA), and the majority have active psoriasis prior to the development of arthritis. Clinical risk factors, such as nail involvement, in conjunction with novel blood biomarkers, could improve PsA risk monitoring and early diagnosis. Objectives: The aim of the HIPPOCRATES Prospective Observational Study (HPOS—www.hpos.study) ...
Preserving joint line orientation in TKA improves short- to mid-term outcomes
Jácome-Pacheco, Dúnio; Torres, Tiago; Rodrigues, Gonçalo; Diniz, Pedro; Guerra-Pinto, Francisco; Camacho, António; Gamelas, João; Seil, RomainPurpose: Joint line orientation (JLO) has been identified as a potential factor influencing clinical outcomes following total knee arthroplasty (TKA). This systematic review and meta-analysis aimed to assess whether preserving the JLO according to the individual knee phenotype is associated with improved clinical and functional outcomes. We hypothesised that joint line preserving (JLP) techniques would result i...
Assessment of Competencies of Clinical Research Professionals and Proposals to ...
Bogas, Mónica; Antas, Joana; Magalhães, Cátia; Revige, Mafalda; Guerra, Liliana; Ribeiro, Cheila; Eça, Rita Cunha; Nunes, Filipa; Lopes, AnaBackground: Clinical studies are coordinated by multidisciplinary teams, which often lack adequate training and competencies. In this study, ROCHE and AICIB (Agency for Clinical Research and Biomedical Innovation) conducted a self-assessment survey aiming to evaluate the competency of clinical research professionals to conduct clinical research in Portugal and promote the identification of key actions to addres...
Update on Generalized Pustular Psoriasis.
Torres, Tiago; Antunes, Joana; Tavares Bello, Rui; Varela, Paulo; Henrique, Martinha; Marques Pinto, Gabriela; Figueiredo, Américo; Correia, OsvaldoGeneralized pustular psoriasis (GPP) is a rare but severe inflammatory skin disease characterized by the eruption of widespread sterile pustules, often accompanied by systemic inflammation. Although GPP can coexist with plaque psoriasis, it is increasingly recognized as a distinct entity with unique clinicopathological, immunologic, and genetic features. The dysregulated IL-36 pathway, including mutations in th...
Portuguese consensus on first line treatment of moderate-to-severe psoriasis wi...
Torres, Tiago; Magina, Sofia; Paiva-Lopes, MariaIntroduction: Psoriasis (PsO) is a common chronic, inflammatory, immune-mediated disease. In 2023, a 4.4% prevalence of PsO was reported in Portugal. Currently, Tumor Necrosis Factor inhibitors (TNFi) are the recommended first-line (1 L) biologic agents in Portugal given their lower cost. However, TNFi may not be suitable for several patients. In these patients, interleukin inhibitors (ILi) should be considered...
Letter to the Editor – “Guidelines for Management of Patients with Hidradenitis...
Matos, João; Furtado, Isabel; Torres, Tiago; Vasconcelos, António Ludgero; Araújo Abreu, MiguelN/a.; N/a.
How Can We Improve Care for Patients with Atopic Dermatitis in Portugal?
Torres, TiagoN/a.; N/a.
Dupilumab in Patients with Atopic Dermatitis: A Multicentric, Long-Term, Real-W...
Torres, Tiago; Cruz, Maria João; Gonçalo, Margarida; Filipe, Paulo; Duarte, Bruno; Alves, João; Alvarenga, José Miguel; Rosa, Gilberto; Flor, DuarteIntroduction: Several clinical trials have established the efficacy and safety of dupilumab for treating atopic dermatitis (AD). However, literature remains scarce in reporting the long-term effectiveness, safety, and drug survival of dupilumab in real-world settings. This study aimed to describe the latter outcomes of dupilumab in patients with AD. Methods: This Portuguese, multicentric, observational, retrosp...
Influence of clinical and psychosocial factors on the adherence to topical trea...
Teixeira, Ana; Teixeira, Maribel; Gaio, Rita; Torres, Tiago; Magina, Sofia; Dinis, Maria Alzira Pimenta; Sousa-Lobo, José; Almeida, IsabelPsoriasis is a common chronic inflammatory skin disease with different manifestations, affecting the quality of life at social, emotional, and professional dimensions and requiring long-term treatment. This study aimed to investigate the effect of psychosocial and clinical factors on adherence to topical treatment in psoriasis. Self-reported measures and weighing the medicines were used to assess adherence. Psy...
A Narrative Review of the OX40-OX40L Pathway as a Potential Therapeutic Target ...
Abdelhalim, Asaad; Yilmaz, Orhan; Elshaikh Berair, Mohamed; Torres, TiagoAtopic dermatitis (AD) is a common chronic inflammatory skin disease involving complex immune dysregulation, including the OX40-OX40L pathway. Rocatinlimab and amlitelimab, monoclonal antibodies targeting OX40 and OX40L, respectively, have shown promise in treating moderate-to-severe AD. Both therapies have demonstrated significant efficacy in reducing disease severity, with favorable safety profiles and no ser...