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Building better biobetters: from fundamentals to industrial application

Torres-Obreque, Karin M.; Meneguetti, Giovanna P.; Muso-Cachumba, Jorge J.; Feitosa, Valker A.; Santos, João H. P. M.; Ventura, Sónia P. M.

Biological drugs or biopharmaceuticals off patent open a large market for biosimilars and biobetters, follow-on biologics. Biobetters, in particular, are new drugs designed from existing ones with improved properties such as higher selectivity, stability, half-life and/or lower toxicity/immunogenicity. Glycosylation is one of the most used strategies to improve biological drugs, nonetheless bioconjugation is an...

Date: 2022   |   Origin: RIA - Repositório Institucional da Universidade de Aveiro
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