7 documents found, page 1 of 1
A Common Variant in the CDK8 Gene Is Associated with Sporadic Pituitary Adenoma...
Gaspar, L; Gonçalves, C; Fonseca, F; Carvalho, D; Cortez, L; Palha, A; Barros, I; Nobre, E; Duarte, J; Amaral, C; Bugalho, MJ; Marques, O; Pereira, BThe majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the NEBL (rs2359536), PCDH15 (rs10763170) and CDK8 (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was t...
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs again...
Gaspar, L; Coron, R; KongThoo Lin, P; Costa, DM; Perez-Cabezas, B; Tavares, J; Roura-Ferrer, M; Ramos, I; Ronin, C; Major, L; Ciesielski, FChagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region’s leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to control the disease. S...
Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei
Loureiro, I; Thoo-Lin, P; Ramos, I; Roura, M; Pruvost, A; Pemberton, I; Loukil, H; MacDougall, J; Tavares, J; Cordeiro-da-Silva, A; Graça, NA; Gaspar, LCurrent treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against Trypanosoma brucei. BNIPDiaminobutane (BNIPDabut), the most active of these compounds, showed in vitro inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pe...
Current and future chemotherapy for chagas disease
Gaspar, L; Moraes, C; Freitas-Junior, L; Ferrari, S; Costantino, L; Costi, M; Coron, R; Smith, TK; Siqueira-Neto, J; McKerrow, J; Cordeiro-da-Silva, AHuman American trypanosomiasis, commonly called Chagas disease, is one of the most neglected illnesses in the world and remains one of the most prevalent chronic infectious diseases of Latin America with thousands of new cases every year. The only treatments available have been introduced five decades ago. They have serious, undesirable side effects and disputed benefits in the chronic stage of the disease - a ...
Diffuse hyperplasia of the thymus after chemotherapy for Hodgkin's disease.
Moreira, J R; Brito, U; Rosado, J; Gaspar, L; Soromenho, F
Hiperplasia Difusa do Timo Após Quimioterapia a Doença de Hodgkin
Moreira, JR; Brito, U; Rosado, J; Gaspar, L; Soromenho, FOs autores descrevem um caso de um doente de 23 anos com linfoma de 1-Iodgkin de celularidade mista num estádio II-B que após quimioterapia desenvolveu uma massa mediastínica, cuja histologia revelou tratar-se de uma hiperplasia do timo.
Effectiveness of radiotherapy in non-resectable cavernous hemangioma of the liver.
Mascarenhas, F; Gaspar, L; Da Costa, M S; Afonso, J G; Silvestre, M EIn the management of the unresectable cavernous hemangioma of the liver, the Radiotherapy has an important role. This paper reports the experience of Radiotherapy department of Hospital Santa Maria. The authors review retrospectively the literature concerning techniques, results and complications of this therapy and analyse other possible attitudes in treatment of these lesions.; In the management of the unrese...