21 documents found, page 1 of 3
K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom
Pereira, Ticiana Praciano; Campos, Adriana Rolim; Leal, Luzia Kalyne A. M.; Pierdoná, Taiana Magalhães; Toyama, Marcos H. [UNESP]Made available in DSpace on 2022-04-28T21:24:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01; The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect durin...
Cytotoxicity of active ingredients extracted from plants of the Brazilian Cerrado
Soares, Veronica C.G.; Bonacorsi, Cibele [UNESP]; Andrela, Alana L.B.; Bortoloti, Lígia V.; De Campos, Stepheny C.; Fagundes, Fábio H.R.Made available in DSpace on 2022-04-29T00:50:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01; Cytotoxicity assays are needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian cerrado. The viability was assayed with the neutral red uptake assay in Mac ...
A catalytically inactive Lys49 PLA2 isoform from Bothrops jararacussu venom tha...
Fagundes, Fabio H. R. [UNESP]; Aparício, Ricardo; Dos Santos, Marcelo L.; Filho, Eduardo B. S. Diz [UNESP]; Oliveira, Simone C. B. [UNESP]Made available in DSpace on 2022-04-29T00:50:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-01; A new secretory phospholipase A2 (sPLA2) isoform from Bothrops jararacussu venom (BjVIII) has been characterized by causing platelet aggregation, an absent activity in BthTx-I, Prtx-I and PrTx-II sPLA2s. According to our results, BjVIII also enhances insulin release by the pancreatic beta cells. The com...
In vitro studies on Bothrops venoms cytotoxic effect on tumor cells
Jorge, Roberta J. B.; Martins, Alice M. C.; Morais, Isabel C. O.; Ximenes, Rafael M.; Rodrigues, Felipe A. R.; Soares, Bruno M.Made available in DSpace on 2022-04-29T02:17:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-29; Background: Animal venoms are complex mixtures of proteins and non proteins components with several biological activities. Snake venoms represent an essentially unexplored source of bioactive compounds that may cure disease conditions which do not respond to currently available therapies. These venoms p...
Influence of lysosomal protease sensitivity in the immunogenicity of the antitu...
Rodrigues, Mariane A.D.; Pimenta, Marcela V.; Costa, Iris M.; Zenatti, Priscila P.; Migita, Natacha A.; Yunes, José A.; Rangel-Yagui, Carlota O.Made available in DSpace on 2021-06-25T10:35:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ministério da Ciência, Tecnologia, Inovações e Comunicações; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); L-asparaginase (ASNase) from Escherichia ...
From sperm plug formation to ovulation: Morphological and ultrastructural modif...
Assugeni, Camila O. [UNESP]; Toyama, Marcos H. [UNESP]; Zara, Fernando J. [UNESP]Made available in DSpace on 2021-06-25T10:53:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; In species of Callinectes a sperm plug is formed in the seminal receptacle (SR) during the sperm transfer, which hinders the insemination by other males. In this study, we evaluated the morphology, histochemistry, and ultrastructure of the seminal receptacle of juvenile and adult females of Callinectes ...
Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredox...
Tairum, Carlos A. [UNESP]; Santos, Melina Cardoso [UNESP]; Breyer, Carlos A. [UNESP]; Ryan Geyer, R.; Nieves, Cecilia J.; Portillo-Ledesma, StephanieMade available in DSpace on 2018-11-26T17:06:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-09-15; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Typical 2-Cys Peroxiredoxins (2-Cys Prxs) reduce hydroperoxides with extraordinary rates due to an active site composed of a catalytic triad, containing a peroxidatic cysteine (CP), an Arg, and a Thr (or Ser). 2-Cys Prx are involved in proce...
Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Le...
Bordon, Maria L.A.C. [UNESP]; Laurenti, Márcia D.; Ribeiro, Susan Pereira; Toyama, Marcos H. [UNESP]; Toyama, Daniela de O.Made available in DSpace on 2018-12-11T17:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-27. Added 1 bitstream(s) on 2021-07-15T15:22:08Z : No. of bitstreams: 1 S1678-91992018000100312.pdf: 922596 bytes, checksum: 18fb86fe456fe9c71e3e438fca44c19d (MD5); Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses ...
Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothel...
Martins, René Duarte; Jorge, Roberta Jeane Bezerra; Alves, Renata de Sousa; Silva Neto, Antônio Gomes da; Barbosa, Paulo Sergio F.Made available in DSpace on 2018-12-11T17:14:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01; Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular e...
Non-clinical studies for evaluation of 8-C-rhamnosyl apigenin purified from pep...
Tamayose, Cinthia I.; Romoff, Paulete; Toyama, Daniela O.; Gaeta, Henrique H. [UNESP]; Costa, Caroline R. C. [UNESP]; Belchor, Mariana N. [UNESP]Made available in DSpace on 2018-12-11T17:14:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-09-14; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Compound 8-C-rhamnosyl apigenin (8CR) induced a moderate reduction in the enzymatic activity of secretory phospholipase A2 (sPLA2) from Crotalus durissus terrificus and cy...