48 documents found, page 1 of 5
Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related ...
Traina, Fabiola
Molecular-based score inspired on metabolic signature improves prognostic strat...
Traina, Fabiola
Irs1S57X heterozygous mutant mice display normal hematopoiesis and phenotypic f...
Traina, Fabiola
NTAL is associated with treatment outcome, cell proliferation and differentiati...
Traina, Fabiola
Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
Traina, Fabiola
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-p...
Traina, Fabiola
IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK...
Traina, Fabiola
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
Machado-Neto, João Agostinho; Fenerich, Bruna Alves; Alves, Ana Paula Nunes Rodrigues; Fernandes, aqueline Cristina; Scopim-Ribeiro, RenataThe insulin receptor substrate (IRS) proteins are a family of cytoplasmic proteins that integrate and coordinate the transmission of signals from the extracellular to the intracellular environment via transmembrane receptors, thus regulating cell growth, metabolism, survival and proliferation. The PI3K/AKT/mTOR and MAPK signaling pathways are the best-characterized downstream signaling pathways activated by IRS...
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
Traina, Fabiola
IRAK1 expression in bone marrow cells does not impact patient outcomes in myelo...
Traina, Fabiola