29 documents found, page 1 of 3
ENHANCED RECOVERY AFTER SURGERY: A TRUE REVOLUTION AT COIMBRA UNIVERSITY AND HO...
Silva, Luísa; Almeida, Ana; Rosete, Manuel; Correia, Filipa; Tralhão, José GuilhermeA small group of anesthesiologists and surgeons from Coimbra University and Hospital Center became interested in a project developed in northern European countries, the Enhanced Recovery After Surgery (ERAS®) Program. This program is based on training and preparing colorectal surgical patients with excellent results with regard to the decrease of complications, duration of hospitalization and the increase of pa...
LOCO-REGIONAL APPROACH IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA
Alves Vaz, Ana Luísa; Martins, Rui Miguel; Tralhão, José GuilhermeHepatocellular carcinoma ranks 5th in terms of the most frequent neoplasms, currently constituting one of the main causes of death from cancer. The vast investigation and growing knowledge on the mechanisms of this neoplasia, allowed the development of a set of therapies, which can be used alone or combined, thus contributing to a change in the treatment paradigm for these patients. Liver resection is the metho...
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA ...
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo Cerqueira de; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; Branco, Ana; Seabra, CátiaEndothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of microRNA (miR) mimics and identified 25 miRs capable of enhancing the survival of ECs exposed to ischemia-mimicking conditions. In vitro, we showed that miR-425-5p, ...
The Impact of the Enhanced Recovery After Surgery (ERAS) Protocol on Colorectal...
Lopes, Catarina; Vaz Gomes, Mariana; Rosete, Manuel; Almeida, Ana; Silva, Luisa Isabel; Tralhão, José GuilhermeIntroduction: The benefits of the multimodal Enhanced Recovery After Surgery® (ERAS) program have been described all over the world. The adoption of several perioperative strategies translates into an improvement in the quality of the healthcare provided. The aim of this study was to report the results of the implementation of the ERAS® program for colorectal surgery in a tertiary hospital.Material and Methods:...
ABDOMINAL WALL CATASTROPHE, THERAPEUTIC STRATEGY – A CASE REPORT AND REVIEW OF ...
Amaral, Maria João; Serôdio, Marco; Ramos, Sara; Manso, António; Alexandrino, Henrique; Tralhão, José GuilhermeA complete abdominal wall defect (AWD) is life-threatening, has a functional and cosmetic impact on patients’ quality of life and represents a significant challenge for surgeons, requiring a multidisciplinary treatment strategy. The goals of the reconstructive surgery in the management of these defects are to provide stable coverage of the abdominal contents, restore function and achieve complete wound closure....
ASSOCIATING LIVER PARTITION AND PORTAL VEIN LIGATION (ALPPS) FOR COLORECTAL LIV...
Ruivo, Ana; Nemésio, Rodrigo; Martins, Ricardo; Pinho, António; Tralhão, José GuilhermeThe associating liver partitioning and portal vein ligation for staged hepatectomy has gained interest in the treatment of unresectable colorectal liver metastases as it has allowed to expand the limits of oncological resectability. Despite the initial poor outcomes associated to this procedure, recent reports have showed reduced morbimortality in well selected patients. The current study evaluates the outcomes...
Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees ...
Silva-Vaz, Pedro; Jarak, Ivana; Rato, Luis; Oliveira, Pedro F.; Morgado-Nunes, Sara; Paulino, Aida; Castelo-Branco, Miguel; Botelho, FilomenaAcute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. Twenty-nine patients with biliary AP and 11 heal...
Technical requirements for a safe performance of TAMIS during COVID-19 pandemic...
Amaral, Maria João; Vaz, Mariana; Manso, António; Rosete, Manuel; Gonçalves, Nídia; Serôdio, Marco; Tralhão, José GuilhermeCoronavirus disease 2019 (COVID-19) pandemic is challenging healthcare systems. Surgical care during the COVID-19 pandemic presents numerous challenges regarding not only patient and community safety, but also the safety of physicians and operating room (OR) staff. In the OR, general anaesthesia poses a risk of aerosolization during the intubation process. There is also concern about minimally invasive surgery ...
The role of mouse models in colorectal cancer research-The need and the importa...
Oliveira, Rui C.; Abrantes, Ana Margarida; Tralhão, José Guilherme; Botelho, Maria FilomenaColorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, ...
Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastase...
Temido, Maria José; Oliveira, Rui Caetano; Martins, Ricardo; Serôdio, Marco; Costa, Beatriz; Carvalho, César; Santos, Eva; Ferreira, LuísPurpose: Hepatectomy (Hp) is an alternative approach for the treatment of gastric carcinoma liver metastases (GCLM). However, prognostic factors that may assist patient selection are still controversial. Several pathologic features, such as the growth pattern (GP), associated with prognosis in colorectal cancer liver metastases, were never investigated in GCLM. Our principal aim was to assess if the GP has prog...