37 documents found, page 1 of 4
Lymph Node Metastases in Papillary Thyroid Microcarcinoma: Case Report
da Costa, Ana Isabel Valente; Quental, Carla; Martins, Maria João; Almeida, João; Tralhão, José GuilhermePapillary thyroid carcinoma is a frequent incidental finding after thyroidectomy and is associated with a good prognosis. The authors present a clinical case of a female 54-year-old patient who underwent total thyroidectomy for a non-toxic multinodular goiter with pathological diagnosis of incidental, bifocal, classic papillary microcarcinoma, with tall cell focus, at that time classified as pT3(m); R0, AJCC/TM...
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Perez-Rojas, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C; Frazão, Laura P; Peixoto, CarolinaBackground/objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable access to care. This study aims to enhance pa...
Duodenal Duplication Cyst in Adulthood: Case Report and Brief Review of Literature
Lopes, Catarina; Nogueira, Oriana; Rosete, Manuel; Pinho, António; Tralhão, José GuilhermeN/a.; N/a.
ENHANCED RECOVERY AFTER SURGERY: A TRUE REVOLUTION AT COIMBRA UNIVERSITY AND HO...
Silva, Luísa; Almeida, Ana; Rosete, Manuel; Correia, Filipa; Tralhão, José GuilhermeA small group of anesthesiologists and surgeons from Coimbra University and Hospital Center became interested in a project developed in northern European countries, the Enhanced Recovery After Surgery (ERAS®) Program. This program is based on training and preparing colorectal surgical patients with excellent results with regard to the decrease of complications, duration of hospitalization and the increase of pa...
Clinical Impact of Preoperative Biliary Drainage in Patients with Ductal Adenoc...
Amaral, Maria João; Freitas, João; Amaral, Mariana; Serôdio, Marco; Oliveira, Rui Caetano; Donato, Paulo; Tralhão, José GuilhermeOur aim was to study the association between preoperative biliary drainage (PBD) and morbidity following cephalic pancreaticoduodenectomy (CPD) for pancreatic ductal adenocarcinoma (PDAC) and its prognostic impact, which is still controversial in the literature. A retrospective study was conducted, which included 128 patients who underwent CPD for PDAC, divided into two groups: those who underwent PBD (group 1)...
The Impact of the Enhanced Recovery After Surgery (ERAS) Protocol on Colorectal...
Lopes, Catarina; Vaz Gomes, Mariana; Rosete, Manuel; Almeida, Ana; Silva, Luisa Isabel; Tralhão, José GuilhermeIntroduction: The benefits of the multimodal Enhanced Recovery After Surgery® (ERAS) program have been described all over the world. The adoption of several perioperative strategies translates into an improvement in the quality of the healthcare provided. The aim of this study was to report the results of the implementation of the ERAS® program for colorectal surgery in a tertiary hospital. Material and Methods...
Tumor Stroma Area and Other Prognostic Factors in Pancreatic Ductal Adenocarcin...
Amaral, Maria João; Amaral, Mariana; Freitas, João; Oliveira, Rui Caetano; Serôdio, Marco; Cipriano, Maria Augusta; Tralhão, José GuilhermePancreatic ductal adenocarcinoma (PDAC) has a dense stroma, responsible for up to 80% of its volume. The amount of stroma can be associated with prognosis, although there are discrepancies regarding its concrete impact. The aim of this work was to study prognostic factors for PDAC patients submitted to surgery, including the prognostic impact of the tumor stroma area (TSA). A retrospective study with PDAC patie...
Innate Immune Cells in the Tumor Microenvironment of Liver Metastasis from Colo...
Sampaio-Ribeiro, Gabriela; Ruivo, Ana; Silva, Ana; Santos, Ana Lúcia; Oliveira, Rui Caetano; Gama, João; Cipriano, Maria AugustaColorectal cancer (CRC) is the third most prevalent type of cancer, and liver metastasis is the most common site of metastatic development. In the tumor microenvironment (TME), various innate immune cells are known to influence cancer progression and metastasis occurrence. CD274 (PD-L1) and CD206 (MRC1) are proteins that have been associated with poor prognosis and disease progression. We conducted a study on t...
Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, ...
Amaral, Maria João; Oliveira, Rui C.; Donato, Paulo; Tralhão, José GuilhermePancreatic cancer is one of the most fatal malignancies, as approximately 80% of patients are at advanced stages by the time of diagnosis. The main reason for the poor overall survival is late diagnosis that is partially due to the lack of tools for early-stage detection. In addition, there are several challenges in evaluating response to treatment and predicting prognosis. In this article, we do a review of th...
LOCO-REGIONAL APPROACH IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA
Alves Vaz, Ana Luísa; Martins, Rui Miguel; Tralhão, José GuilhermeHepatocellular carcinoma ranks 5th in terms of the most frequent neoplasms, currently constituting one of the main causes of death from cancer. The vast investigation and growing knowledge on the mechanisms of this neoplasia, allowed the development of a set of therapies, which can be used alone or combined, thus contributing to a change in the treatment paradigm for these patients. Liver resection is the metho...