4 documents found, page 1 of 1
SURGICAL RESOLUTION AFTER MULTIMODAL TREATMENT IN A DOG WITH GRANULOMATOUS NODU...
Guimarães, Tarcísio; Cardoso, Karla; Botelho, Filomena; Laranjo, Mafalda; Rozin, A.; Tralhão, Pedro; Alexandre, NunoIntroduction Granulomatous nodular episcleritis(GNE) is a mixed lymphocytic and granulomatous nodular inflammation of the conjunctiva or adjacent sclera4, rarely described in dogs. Defined as an idiopathic conjunctiva and scleral primary disease, is presumed to be an immune-mediated disorder; although may also be derived from secondary disease1.Clinically characterized by an elevated, non-painful, single or mul...
Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in...
Guimarães, Tarcísio Guerra; Cardoso, Karla Menezes; Tralhão, Pedro; Marto, Carlos Miguel; Alexandre, Nuno; Botelho, Maria Filomena; Laranjo, MafaldaNeoplasms of melanocytic origin are diseases relevant to dogs and cats' ophthalmic oncology due to their incidence, potential visual loss, and consequent decrease in life quality and expectancy. Despite its non-specific clinical presentation, melanocytic neoplasms can be histologically distinguished in melanocytomas, which present benign characteristics, and malignant melanomas. The diagnosis often occurs in ad...
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate micr...
Boia, Raquel; Elvas, Filipe; Madeira, Maria H.; Aires, Inês D.; Rodrigues-Neves, Ana C.; Tralhão, Pedro; Szabó, Eszter C; Baqi, YounisTransient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness. Evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia-reperfusion (I-R). The...
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiolo...
Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; Cavadas, CláudiaNeuropeptide Y (NPY) is expressed in mammalian retina but the location and potential modulatory effects of NPY receptor activation remain largely unknown. Retinal ganglion cell (RGC) death is a hallmark of several retinal degenerative diseases, particularly glaucoma. Using purified RGCs and ex vivo rat retinal preparations, we have measured RGC intracellular free calcium concentration ([Ca2+]i) and RGC spiking ...