2 documents found, page 1 of 1
Is the proteome of bronchoalveolar lavage extracellular vesicles a marker of ad...
Carvalho, Ana Sofia; Moraes, Maria Carolina Strano; Hyun Na, Chan; Fierro-Monti, Ivo; Henriques, Andreia; Zahedi, Sara; Bodo, CristianAcellular bronchoalveolar lavage (BAL) proteomics can partially separate lung cancer from non-lung cancer patients based on principal component analysis and multivariate analysis. Furthermore, the variance in the proteomics data sets is correlated mainly with lung cancer status and, to a lesser extent, smoking status and gender. Despite these advances BAL small and large extracellular vehicles (EVs) proteomes r...
Over-elongation of centrioles in cancer promotes centriole amplification and ch...
Marteil, Gaëlle; Guerrero, Adan; Vieira, André F; de Almeida, Bernardo P; Machado, Pedro; Mendonça, Susana; Mesquita, Marta; Villarreal, BethCentrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amp...