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Gene expression analysis of peripheral blood leukocytes from discordant sib-pai...

Middleton, Frank A.; Pato, Carlos N.; Gentile, Karen L.; McGann, Lindsay; Brown, Andrea M.; Trauzzi, Marco; Diab, Heba; Morley, Christopher P.

We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorde...


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