Jatropha mollissima (Pohl) Baill. is a native plant of the Brazilian semiarid that belongs to the Euphorbiaceae family. It is a widely distributed monoecious occurring in all states of Northeast Brazil, except Maranhão, and inhabiting areas of caatinga and restinga. In order to add information about this species as well as to facilitate their identification, this study aimed to determine the biometrics, to desc...
his study aimed to assess the possible systemic antinociceptive activity of mangiferin and to clarify the un- derlying mechanism, using the acute models of chemical (acetic acid, formalin, and capsaicin) and thermal (hot-plate and tail- fl ick) nociception in mice. Mangiferin at oral doses of 10 to 100 mg/kg evidenced signif- icant antinociception against chemogenic pain in the test models of acetic acid-induce...
AIM: To investigate the effects of mangiferin on gas - trointestinal transit (GIT) in normal and constipated mice, together with the possible mechanism. METHODS: Intragastrically-administered charcoal mea was used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin (3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po ) or tegaserod (1 mg/kg, ip ) were administered 30 min before the c...