4 documents found, page 1 of 1
Infection with Leishmania major induces interleukin-12 production in vivo.
Vieira, Leda Quercia; Hondowicz, Brian D.; Afonso, Luís Carlos Crocco; Wysocka, Maria; Trinchieri, Giorgio; Scott, PhillipExperimental infections of mice with the protozoan parasite Leishmania major provide an excellent model for defining the conditions required for generation of CD4 ÷ Thl and Th2 cells in vivo. Since interleukin-12 (IL-12) has been implicated in the development of Thl cells, we investigated whether L. major stimulates IL-12 production in vitro or in vivo. Surprisingly, macrophages cultured in vitro failed to prod...
A recombinant leishmania antigen that stimulates human peripheral blood mononuc...
Skeiky, Yasir A. W.; Guderian, Jeffrey A.; Benson, Darin R.; Bacelar, Olivia; Carvalho Filho, Edgar Marcelino de; Kubin, Marekp. 1527-1537; Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-16T17:27:13Z No. of bitstreams: 1 11111aaw.pdf: 2505648 bytes, checksum: 5976238837c366626c39bab0545a89c0 (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-03T15:02:35Z (GMT) No. of bitstreams: 1 11111aaw.pdf: 2505648 bytes, checksum: 5976238837c366626c39bab0545a89c0 (MD5); Made available...
A recombinant Leishmania antigen that stimulates human peripheral blood mononuc...
Skeiky, Y. A.; Guderian, J. A.; Benson, Darin R.; Bacelar, Olivia; Carvalho Filho, Edgar Marcelino de; Kubin, M.; Badaró, Roberto José da SilvaTexto completo: acesso restrito. p.1527-1537; Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-18T16:53:37Z No. of bitstreams: 1 skeiky.pdf: 1216564 bytes, checksum: 199645b04071218b89a43b6f6951d600 (MD5); Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-20T13:54:27Z (GMT) No. of bitstreams: 1 skeiky.pdf: 1216564 bytes, checksum: 199645b04071218b89a43...
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, ...
Boonstra, André; Rajsbaum, Ricardo; Holman, Mary; Marques, Rute; Asselin-Paturel, Carine; Pereira, João Pedro; Bates, Elizabeth E. M.; Akira, ShizuoWe have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic DC produce substantially lower levels of this cytokine when activated with the TLR-9 ligand CpG. We now show that in response to CpG stimulation, high levels of IL-10 are secreted by macrophages, intermediate levels by myeloid DC, but no detectable IL-10 is...