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Contribution of the adenine nucleotide carrier, porin, and sphingolipid metabol...

A decisive event in the cell‟s life-or-death decision is the mitochondrial outer membrane permeabilization (MOMP). The biochemical events responsible for MOMP, considered by many investigators the “point-of-no-return” in cell death, are not entirely defined. Two major and very distinct mechanisms have been implicated in the control of MOMP: i) the action of Bcl-2 family proteins, which can directly engage the o...

Role of ceramides and ceramides-formed pores in the process of mitochondria per...

Ceramides are second messengers of different physiological processes. Some ceramides species can have a pro-apoptotic function involving mitochondria. Indeed, ceramides are able to form pores in artificial lipid bilayers and mitochondria. Furthermore, it has been recently demonstrated that the disassembly of these pores is stimulated by anti-apoptotic proteins of the Bcl-2 family. Ceramides signaling is general...

Assessment of oxidative modification of the Aac2p carrier and its contribution ...

Papel da Aquagliceroporina Fps1 na sensibilidade ao Etanol de Saccharomyces cer...

A aquaglicerporina Fps1 é um membro da família de proteínas-canal MIP, e um conhecido facilitador do transporte de glicerol. Recentemente foi também apontada como um elemento importante na resistência das leveduras ao ácido acético, num processo que inclui a sua remoção da membrana plsmática, após fosforilação mediada pela Hog1 MAP cinase. Num trabalho anterior verificou-se que células de S. cerevisiae apresent...