9 documents found, page 1 of 1

Endothelial dysfunction in cardiovascular diseases: mechanisms and in vitro models

Endothelial cells (ECs) are arranged side-by-side to create a semi-permeable monolayer, forming the inner lining of every blood vessel (micro and macrocirculation). Serving as the first barrier for circulating molecules and cells, ECs represent the main regulators of vascular homeostasis being able to respond to environmental changes, either physical or chemical signals, by producing several factors that regula...

Application of Proteogenomics to Urine Analysis towards the Identification of N...

To identify new protein targets for PCa detection, first, a shotgun discovery experiment was performed to characterize the urinary proteome of PCa patients. This revealed 18 differentially abundant urinary proteins in PCa patients. Second, selected targets were clinically tested by immunoblot, and the soluble E-cadherin fragment was detected for the first time in the urine of PCa patients. Third, the proteogeno...

Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Propert...

Native biofluid peptides offer important information about diseases, holding promise as biomarkers. Particularly, the non-invasive nature of urine sampling, and its high peptide concentration, make urine peptidomics a useful strategy to study the pathogenesis of renal conditions. Moreover, the high number of detectable peptides as well as their specificity set the ground for the expansion of urine peptidomics t...

A non-parametric analysis for the identification of differentially expressed pr...

Codon misreading tRNAs promote tumor growth in mice

Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, raising the hypothesis that protein synthesis efficiency and accuracy (mistranslation) are compromised in tumors. We show here that human colon tumors and xenograft tumors produced in mice by two epithelial cancer cell lines mistranslate 2- to 4-fold more frequently than normal tissue. To clarify if protein mistra...

VARIAÇÃO SAZONAL E INFLUÊNCIA DE FATORES METEOROLÓGICOS NA INCIDÊNCIA DE DESCOL...

OBJETIVOS Analisar a variação sazonal e a influência de fatores meteorológicos na incidência a 5 anos de descolamento regmatógeno da retina (DRR), na região centro do país e região autónoma da Madeira (RAM). MÉTODOS Série de casos consecutiva, retrospetiva e multicêntrica. Incluíram-se doentes submetidos a cirurgia de DRR no Centro Hospitalar e Universitário de Coimbra e Hospital Doutor Nélio Mendonça entre Jan...

Cross-species comparison of mammalian saliva using an LC-MALDI based proteomic ...

Salivary peptidomic as a tool to disclose new potential antimicrobial peptides

Comparative proteomic analyses of urine from rat urothelial carcinoma chemicall...