Encontrados 4 documentos, a visualizar página 1 de 1
Phenotype of BTK‐lacking myeloid cells during prolonged COVID‐19 and upon conva...
Gomes, André; Farias, Guilherme B.; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Lessa Simões, MarianaXLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells ty...
Gomes, André; Farias, Guilherme B.; Dias Silva, Manuel; Laia, Joel; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of ci...
Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence...
Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; Santos, DianaMonocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison ...
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cel...
Trombetta, Amelia Chiara; Farias, Guilherme B.; Gomes, André; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, JoelAfter more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanis...