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Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia-From Molec...

Alves, Raquel; Gonçalves, Ana Cristina; Rutella, Sergio; Almeida, António M; De Las Rivas, Javier; Trougakos, Ioannis P; Sarmento-Ribeiro, Ana Bela

Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy recognized to be associated with a genetic alteration, the t(9;22)(q34;q11). This translocation originates the BCR-ABL1 fusion gene, encoding the cytoplasmic chimeric BCR-ABL1 protein that displays...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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