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Quantitative trait locus analysis of parasite density reveals that HbS gene car...
do Sambo, Maria Rosário; Penha-Gonçalves, Carlos; Trovoada, Maria Jesus; Costa, João; Lardoeyt, Roberto; Coutinho, AntónioHaemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality. Multiple HbS effects have been described resulting in protection against parasitaemia and reduction of severe malaria risk. This study aimed to explore HbS protection against severe malaria and Plasmodium falciparum parasitaemia in Angolan children exhibiting different severe malaria syndromes.
Modeling Malaria Infection and Immunity against Variant Surface Antigens in Prí...
Trovoada, Maria Jesus; Gonçalves, Lígia A.; Marinho, Cláudio R. F.; Turner, Louise; Hviid, Lars; Penha-Gonçalves, Carlos; Gomes, M. Gabriela M.After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membran...
Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors f...
Sambo, Maria Rosário; Trovoada, Maria Jesus; Benchimol, Carla; Quinhentos, Vatúsia; Gonçalves, Lígia; Velosa, Rute; Marques, Maria IsabelBACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. Nevertheless, susceptibility to experimental CM in the mouse has been linked to host genes including T...
Insights from pattern of mtDNA variation into the genetic history of São Tomé e...
Trovoada, Maria Jesus; Pereira, Luísa; Gusmão, Leonor; Abade, Augusto; Amorim, António; Prata, Maria JoãoSequence data from the hypervariable segments I (HVS-I) and II (HVS-II) was obtained for 30 Angolares, 35 Forros and 38 Tongas, three self-reported ethnic groups from São Tomé e Príncipe, an African archipelago (Gulf of Guinea) whose settlement begun in the late 15th century. The repertory of mtDNA lineages denoted a fully African maternal pool primarily arisen from a Central/Southwestern substratum. The absenc...