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Metabolic reprogramming regulates histone lactylation during zebrafish caudal f...
Borbinha, Jorge; Lourenço, Raquel; Brandão, Ana S.; Ribeiro, Daniel; Carvalho, Ana Sofia; Matthiesen, Rune; Jacinto, AntónioTissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating gene expression across various biological processes. Here, we report an increase in global histone lactylation in the mesenchyme and osteoblasts of the zebrafish caudal ...
Neutrophils matter
Correia, Bruna F.; Grosa, Daniela; Salvador, Rute; Brites, Inês; Martins, Telma; Vitorino, Marina; Sousa, Carolina Xavier; Cristóvão-Ferreira, SofiaBackground: Metastatic breast cancer (BC) remains a significant clinical challenge, needing innovative strategies to improve disease management. Increased neutrophil levels have been observed in both peripheral blood and tumor tissues of patients with different types of cancer, often being associated with poor clinical outcomes. These findings suggest a crucial role for neutrophils in tumor progression, raising...
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo ...
Domingues, Neuza S.; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P.; Bento, Luís; Marques, André R. A.; Soares, Maria I. L.; Sampaio, JulioOxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of PUFA-esters of cholesterol, the effects of cholesteryl hemiesters (ChEs), the oxidation end products of these esters, have not been studied. Through lipidomics analyses, we identified and quantified two ChE types in the plasma of...
theLiTE™: a screening platform to identify compounds that reinforce tight junct...
Gomes, Teresa Lopes; Oliveira-Marques, Virgínia de; Hampson, Richard John; Jacinto, António; de Moraes, Luciana Vieira; Martinho, Rui GoncaloTight junctions (TJ) are formed by transmembrane and intracellular proteins that seal the intercellular space and control selective permeability of epithelia. Integrity of the epithelial barrier is central to tissue homeostasis and barrier dysfunction has been linked to many pathological conditions. TJ support the maintenance of cell polarity through interactions with the Par complex (Cdc42-Par-6-Par-3-aPKC) in...
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida; Dias, Ana Filipa; Silva, Dalila; Pereira, Telmo; Chapela Pires, DianaPersistent senescent cells (SCs) are known to underlie aging-related chronic disorders, but it is now recognized that SCs may be at the center of tissue remodeling events, namely during development or organ repair. In this study, we show that two distinct senescence profiles are induced in the context of a spinal cord injury between the regenerative zebrafish and the scarring mouse. Whereas induced SCs in zebra...
Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics duri...
Ponte, Susana; Carvalho, Lara; Gagliardi, Maria; Campos, Isabel; Oliveira, Paulo J.; Jacinto, AntónioMitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is linked to several human diseases. In this work, we investigated the role of mitochondrial dynamics in wound healing in the Drosophila embryonic epidermis. Mutants f...
HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to ...
Saraiva, Diana P.; Jacinto, António; Borralho, Paula; Braga, Sofia; Cabral, M. GuadalupePrediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies. Infiltrating T lymphocytes, namely cytotoxic T lymphocytes (CTLs) have been appointed as predictors of response. However, cancer cells have the ability to dampen CTLs' activity and thus, the prognostic value of the CTLs, per se, is debatable. Here, we disc...
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWA...
Abrantes, Patrícia; Santos, Maria M.; Sousa, Inês; Xavier, Joana M.; Francisco, Vânia; Krug, Tiago; Sobral, João; Matos, Mafalda; Martins, MadalenaSubarachnoid hemorrhage (SAH) is a life-threatening event that most frequently leads to severe disability and death. Its most frequent cause is the rupture of a saccular intracranial aneurysm (IA), which is a blood vessel dilation caused by disease or weakening of the vessel wall. Although the genetic contribution to IA is well established, to date no single gene has been unequivocally identified as responsible...
Colectânea de Poemas (1947-1950)
da Cruz, Viriato; Fonseca, Arguinaldo; Mata, Inocência; Neto, Agostinho; Vieira da Cruz, Tomaz; Vieira, Luandino; Cardoso, António; Martins, OvídioA Casa dos Estudantes do Império (CEI) foi criada em 1944, pelo regime anterior, para responder ao reforço do convívio dos estudantes universitários das ex-colónias portuguesas, que não possuíam instituições de ensino superior e que tinham assim que continuar a frequência universitária em Portugal. Este objetivo integrou-se num outro, mais visto, de formação de eleitos que se admitiam virem a ser enquadradoras ...
V-ATPase Proton Pumping Activity Is Required for Adult Zebrafish Appendage Rege...
Monteiro, Joana; Aires, Rita; Becker, Jörg D.; Jacinto, António; Certal, Ana C.; Rodríguez-León, JoaquínThe activity of ion channels and transporters generates ion-specific fluxes that encode electrical and/or chemical signals with biological significance. Even though it is long known that some of those signals are crucial for regeneration, only in recent years the corresponding molecular sources started to be identified using mainly invertebrate or larval vertebrate models. We used adult zebrafish caudal fin as ...