2 documents found, page 1 of 1
Effects of ketamine administration on mTOR and reticulum stress signaling pathw...
Abelaira, Helena M.; Réus, Gislaine Z.; Ignácio, Zuleide M.; Santos, Maria Augusta B. dos; Moura, Airam B. de; Matos, Danyela; Demo, Júlia P.Recent studies show that activation of the mTOR signaling pathway is required for the rapid antide- pressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists. A relationship be- tween mTOR kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded protein response (UPR) has been shown. We evaluate the effects of ketamine administration on the mTOR signaling pathway...
Enteral nutrition discontinuation and outcomes in general critically ill patients
Silva, Marco Antonio; Santos, Saionara da Graca Freitas dos; Tomasi, Cristiane Damiani; Luz, Gabrielle da; Paula, Marcos Marques da SilvaOBJECTIVE: To determine the relationship between enteral nutrition discontinuation and outcome in general critically ill patients. MATERIALS AND METHODS: All patients admitted to a mixed intensive care unit in a tertiary care hospital from May-August 2009 were screened for an indication for enteral nutrition. Patients were followed up until leaving the intensive care unit or a maximum of 28 days. The gastrointe...