3 documents found, page 1 of 1
Anticonvulsant activity of thymoquinone and its structural analogues
Sousa,Damião P. de; Nóbrega,Franklin F. F.; Santos,Camila C. M. P.; Benedito,Rubens B.; Vieira,Ygor W.; Uliana,Marciana P.; Brocksom,Timothy J.It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity o...
The use of benzil to obtain functionalized N-heterocycles
Braibante,Mara E. F.; Braibante,Hugo T. S.; Uliana,Marciana P.; Costa,Carla C.; Spenazzatto,MarceloIn this work, the reactivity of benzil was studied, employing C, N- and N, N-nucleophiles, such as ethyl(3-amino substituted) 2-butenoates 4a-c , (S, Z)-ethyl 3-(1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)but-2-enoate 6, semicarbazide 8 or thiosemicarbazide 10, to evaluate their electrophilic centers as building blocks for the synthesis of the polyfunctionalized heterocyclic compounds, resulting in pyrrolinone 5a...
Oxidation of mono-phenols to para-benzoquinones: a comparative study
Uliana,Marciana P.; Vieira,Ygor W.; Donatoni,Maria Carolina; Corrêa,Arlene G.; Brocksom,Ursula; Brocksom,Timothy J.The oxidation of mono-phenols to para-benzoquinones is of continuing interest due to the existence of numerous natural products containing this structural unit. The chemical reactivity of para-benzoquinones is also noteworthy, as oxidants and dienophiles in the Diels-Alder reaction. We have used for quite some time now, molecular oxygen and catalysis with [CoII(salen)] as the oxidation procedure, but felt the n...