2 documents found, page 1 of 1
Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target App...
Hrynchak, Ivanna; Cocioabă, Diana; Fonseca, Alexandra I.; Leonte, Radu; Carmo, Sérgio do; Cornoiu, Roxana; Falcão, Amílcar; Niculae, DanaAntibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cy...
Fully Automated Production of [68Ga]GaFAPI-46 with Gallium-68 from Cyclotron Us...
Fonseca, Alexandra I.; Alves, Vítor H.; Hrynchak, Ivanna; Alves, Francisco68Ga-based radiopharmaceuticals are routinely used for PET imaging of multiple types of tumors. Gallium-68 is commonly obtained from 68Ge/68Ga generators, which are limited in the quantity of activity produced. Alternatively, gallium-68 can easily be produced on a cyclotron using liquid targets. In this study, we optimized the GMP production of [68Ga]GaFAPI-46 using gallium-68 produced via a standard medical cy...