2 documents found, page 1 of 1
Astrocyte progenitor transplantation promotes regeneration of bulbospinal respi...
Goulão, Miguel; Ghosh, Biswarup; Urban, Mark W.; Sahu, Malya; Mercogliano, Christina; Charsar, Brittany A.; Komaravolu, Sreeya; Block, Cole G.Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of r...
Calcineurin dysregulation underlies spinal cord injury-induced K+ channel dysfu...
Zemel, Benjamin M.; Muqeem, Tanziyah; Brown, Eric V.; Goulão, Miguel; Urban, Mark W.; Tymanskyj, Stephen R.; Lepore, Angelo C.; Covarrubias, ManuelDysfunction of the fast-inactivating Kv3.4 potassium current in dorsal root ganglion (DRG) neurons contributes to the hyperexcitability associated with persistent pain induced by spinal cord injury (SCI). However, the underlying mechanism is not known. In light of our previous work demonstrating modulation ofthe Kv3.4 channel by phosphorylation, we investigatedthe role ofthe phosphatase calcineurin (CaN) using ...