9 documents found, page 1 of 1
Microalgae extracts reduce appetite in zebrafish larvae linked to long-chain fa...
Moxó, Javier Sanz; Fonseca, Ana Catarina; Matos, Gabriela; Saraiva, Jorge; Pereira, Ricardo Nuno Correia; Rocha, Cristina M.R.; Vasconcelos, VítorAppetite modulation is a promising strategy for obesity treatment. The presented research screened 103 microalgae extracts from three strains of microalgae (Chlorella sp., Chlorococcum sp. and Nannochloropsis oceanica) for appetite reducing activity, using high pressure processing and moderate electric fields. Two different feeding assays with zebrafish larvae were applied using either fluorescent labeled lipos...
Bioactive lipids in Dunaliella salina: implications for functional foods and he...
Pais, Rita; Conde, Tiago; Neves, Bruna B.; Pinho, Marisa; Coelho, Marta; Pereira, Hugo; Rodrigues, Alexandre M. C.; Domingues, Pedro; Gomes, Ana MariaDunaliella salina is a green microalga extensively explored for β-carotene production, while knowledge of its lipid composition is still limited and poorly investigated. Among lipids, polar lipids have been highlighted as bioactive phytochemicals with health-promoting properties. This research aimed to provide an in-depth lipidome profiling of D. salina using liquid and gas chromatography coupled with mass spec...
Bioactive lipids in : implications for functional foods and health
Pais, Rita; Conde, Tiago; Neves, Bruna B.; Pinho, Marisa; Coelho, Marta; Pereira, Hugo; Rodrigues, Alexandre M. C.; Domingues, Pedro; Gomes, Ana MariaDunaliella salina is a green microalga extensively explored for β-carotene production, while knowledge of its lipid composition is still limited and poorly investigated. Among lipids, polar lipids have been highlighted as bioactive phytochemicals with health-promoting properties. This research aimed to provide an in-depth lipidome profiling of using liquid and gas chromatography coupled with mass spectrometry. ...
Bioactivity screening of marine cyanobacteria for the isolation of novel compou...
Moreira, Gabriela A.; Rosa, Filipa; Vasconcelos, Vítor; Urbatzka, RalphNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and effective therapeutics has been widely study. Cyanobacteria, previously known as blue-green algae, are known to produce many secondary metabolites including toxins, with applications to the pharmaceutical industry. The aim of this study is to investigate the effect of extract from cyanobacteria to reduce lipid accumulation in a model...
A natural oxadiazine isolated from cyanobacteria kills cancer cells in multicel...
Sousa, Maria Lígia; Preto, Marco; Martins, Rosário; Vasconcelos, Vítor; Linder, Stig; Urbatzka, RalphCyanobacteria are versatile microorganisms that ubiquitously inhabit terrestrial and aquatic ecosystems. They adapt to external threats by mainly producing secondary metabolites. Therefore, cyanobacteria have been recognized as producer of natural products with potential biotechnological applications, such as bioplastics, antifouling, antibiotics, antiprotozoal or anticancer treatment.
Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and perox...
Madureira, Tânia Vieira; Malhão, Fernanda; Simões, Tiago; Pinheiro, Ivone; Lopes, Célia; Gonçalves, José F.; Urbatzka, Ralph; Castro, L. Filipe C.Lipid metabolism involves complex pathways, which are regulated in a similar way across vertebrates. Hormonal and hypolipidemic deregulations cause lipid imbalance from fish to humans, but the underlying mechanisms are far from understood. This study explores the potential of using juvenile brown trout to evaluate the in vivo interferences caused by estrogenic (17α-ethinylestradiol - EE2), androgenic (testoster...
Generation of spheroids of cancer cells for screening of antitumour activity of...
Sousa, Maria Lígia; Preto, Marco; Vasconcelos, Vítor; Martins, Rosário; Linder, Stig; Leão, Pedro; Urbatzka, RalphThe use of 3D cell culture for modelling cancer research is gaining interest, and in particular for screening of bioactive compounds. In the presented work, three compounds isolated from cyanobacteria and 92 chromatographic fractions obtained from crude organic extracts of 28 cyanobacterial strains from the Portuguese coast were tested on multicellular spheroids generated from the human cell lines HCT116 (colon...
Insights into the potential of picoplanktonic marine cyanobacteria strains for ...
Freitas, Sara; Martins, Rosario; Campos, Alexandre; Azevedo, Joana; Osório, Hugo; Costa, Margarida; Barros, Piedade; Vasconcelos, Vitor; Urbatzka, RalphIn this work, we analysed the potential of picoplanktonic marine cyanobacteria strains as a source of anticancer compounds by elucidating the cytotoxic mechanisms of an ethyl acetate fraction of Cyanobium sp. (LEGE06113) and the Synechocystis salina (LEGE06155) on the RKO colon adenocarcinoma cell line.
Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial A...
Freitas, Sara; Martins, Rosario; Costa, Margarida; Leão, Pedro; Vitorino, Rui; Vasconcelos, Vitor; Urbatzka, RalphHierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated.