3 documents found, page 1 of 1
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells ...
Zamame Ramirez, Jofer Andree [UNESP]; Romagnoli, Graziela Gorete [UNESP]; Falasco, Bianca Francisco [UNESP]; Gorgulho, Carolina Mendonça [UNESP]Made available in DSpace on 2020-12-12T02:01:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01; Higher College of Technology; Autophagy is an important mechanism for tumor escape, allowing tumor cells to recover from the damage induced by chemotherapy, radiation therapy, and immunotherapy and contributing to the development of resistance. The pharmacological inhibition of autophagy contributes to ...
17b-Estradiol, a potential ally to alleviate SARS-CoV- 2 infection
Breithaupt-Faloppa, Ana Cristina; Correia, Cristiano de Jesus; Prado, Carla Máximo; Stilhano, Roberta Sessa; Ureshino, Rodrigo PortesConsidering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early...
Autophagy and intermittent fasting: the connection for cancer therapy?
Antunes, Fernanda; Erustes, Adolfo Garcia; Costa, Angelíca Jardim; Nascimento, Ana Carolina; Bincoletto, Claudia; Ureshino, Rodrigo PortesCancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as aut...