5 documents found, page 1 of 1
BthTX-II from Bothrops jararacussu venom has variants with different oligomeric...
Borges, Rafael J. [UNESP]; Salvador, Guilherme H.M. [UNESP]; Campanelli, Henrique B. [UNESP]; Pimenta, Daniel C.; de Oliveira Neto, Mario [UNESP]Made available in DSpace on 2022-04-28T19:44:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-30; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Phospholipases A2 (PLA2s) are found in almost every venomous snake family. In snakebites, some PLA2s can quickly cause local myonecrosis, which may lead to permanent sequelae if antivenom is administered belatedly. They hydrolyse phospholipi...
Unique crystal structure of a novel surfactant protein from the foam nest of th...
Hissa, Denise Cavalcante; Bezerra, Gustavo Arruda; Birner-Gruenberger, Ruth; Silva, Luciano Paulino; Usón, Isabel; Gruber, KarlBreeding by releasing eggs into stable biofoams ("foam nests") is a peculiar reproduction mode within anurans, fish, and tunicates; not much is known regarding the biochemistry or molecular mechanisms involved. Lv-ranaspumin (Lv-RSN-1) is the predominant protein from the foam nest of the frog Leptodactylus vastus. This protein shows natural surfactant activity, which is assumed to be crucial for stabilizing foa...
Plasmodium falciparum apicomplexan-specific glucosamine-6-phosphate n-acetyltra...
Chi, Jordi; Cova, Marta; De Las Rivas, Matilde; Medina, Ana; Junqueira Borges, Rafael [UNESP]; Leivar, Pablo; Planas, Antoni; Usón, IsabelMade available in DSpace on 2021-06-25T10:14:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into glycosylphosphatidylinositol (GPI) glycolipids and Nand O-linked glycans. Apicomplexan parasites have a hexosamine ...
ALEPH: A Network-oriented approach for the generation of fragment-based librari...
Medina, Ana; Triviño, Josep; Borges, Rafael J. [UNESP]; Millán, Claudia; Usón, Isabel; Sammito, Massimo D.Made available in DSpace on 2020-12-12T01:17:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01; The analysis of large structural databases reveals general features and relationships among proteins, providing useful insight. A different approach is required to characterize ubiquitous secondary-structure elements, where flexibility is essential in order to capture small local differences. The ALEPH ...
SEQUENCE SLIDER: Expanding polyalanine fragments for phasing with multiple side...
Borges, Rafael Junqueira [UNESP]; Meindl, Kathrin; Triviño, Josep; Sammito, Massimo; Medina, Ana; Millán, Claudia; Alcorlo, Martin; Hermoso, Juan A.Made available in DSpace on 2020-12-12T02:36:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01; Fragment-based molecular-replacement methods can solve a macromolecular structure quasi-ab initio. ARCIMBOLDO, using a common secondary-structure or tertiary-structure template or a library of folds, locates these with Phaser and reveals the rest of the structure by density modification and autotracing ...