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Clinical-grade peptide-based inhibition of CK2 blocks viability and proliferati...
Perera, Yasser; Melão, Alice; Ramón, Ailyn C.; Vázquez, Dania; Ribeiro, Daniel; Perea, Silvio E.; Barata, João T.Despite remarkable advances in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), relapsed cases are still a major challenge. Moreover, even successful cases often face long-term treatment-associated toxicities. Targeted therapeutics may overcome these limitations. We have previously demonstrated that casein kinase 2 (CK2)-mediated phosphatase and tensin homologue (PTEN) posttranslational inactivatio...
Data: 2020
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Origem: Repositório da Universidade de Lisboa