9 documents found, page 1 of 1
Combined exercise hinders the progression of pulmonary and right heart harmful ...
Leite, Luciano Bernardes; Soares, Leôncio Lopes; Portes, Alexandre Martins Oliveira; Silva, Bruna Aparecida Fonseca da; Dias, Taís RodriguesThe aim of this study was to test whether combined physical exercise training of moderate intensity executed during the devel- opment of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) hinders the progression of pulmonary and right heart harmful functional and structural remodeling in rats. Wistar rats were injected with MCT (60 mg/kg) and after 24 h were exposed to a combined exercise trainin...
Euterpe Oleracea Martius (Açaí) Extract and Resistance Exercise Modulate Cardia...
Meireles, Pilar Barbosa; Miranda, Denise Coutinho; Moura, Anselmo Gomes; Ribeiro, Willian Cruz; Oliveira, Ângela; Leite, Luciano Bernardes; Forte, PedroThe study evaluated the effects of resistance exercise training and açaí supplementation on cardiac parameters in hypertensive animals. Methods: For this study, rats from the Wistar and SHR lines (spontaneously hypertensive rats) were used. The animals were divided into 5 groups: Wistar Control (C); Control Hypertensive (H); Trained Hypertensive (HT); Hypertensive and Supplemented with Açaí (HA); and Hypertensi...
Screening of plants from the Brazilian Atlantic Forest led to the identificatio...
Almeida, Alisson A.; Lima, Graziela D. A.; Simão, Marcos V. R. C.; Moreira, Gabriela A.; Siqueira, Raoni P.; Zanatta, Ana C. [UNESP]Made available in DSpace on 2020-12-12T02:42:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic scre...
Detection of bovine herpesvirus 1 in cumulus-oocyte complexes of cows
Queiroz-Castro, Vanessa L. D.; Costa, Eduardo P. da; Alves, Saullo Vinicius P.; Silva Júnior, Abelardo; Machado-Neves, Mariana; Guimarães, José D.Bovine herpesvirus 1 (BoHV-1) is the causative agent of infectious bovine rhinotracheitis (IBR) and is also associated with reproductive failure. This study investigated the presence of BoHV-1 in cumulus-oocyte complexes (COCs) of naturally-infected cows without clinical signs of IBR. The presence of BoHV-1 in COCs was evaluated by immunofluorescence using confocal laser scanning microscopy. Blood samples and o...
Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives c...
Lima, Graziela Domingues de Almeida; Rodrigues, Michelle Peixoto; Moreira, Gabriela Alves; Mendes, Tiago Antônio de Oliveira; Siqueira, Raoni PaisIt is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions. The compounds were prepared using as the key step the Copper(I)-catalyzed azide (A)-alkyne (A) cycloaddition (C) (CuAAC reaction), also known as click reaction, between alkynylated cinnamic acid derivatives and different benzyl azides. The reactions were c...
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich...
Moreira, Gabriela Alves; Lima, Graziela Domingues de Almeida; Siqueira, Raoni Pais; Barros, Marcus Vinícius de AndradeThe Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential as promising drug targets. In this context, we have previously selected three trifluoromethyl arylamides (named here as SRVIC24, SRVIC30 and S...
Ultrastructure and morphometric features of epididymal epithelium in Desmodus r...
Castro, Mariana Moraes de; Gonçalves, Wagner Gonzaga; Teixeira, Stéphanie Asséf Millen Valente; Queiroz Fialho, Maria do Carmo; Santos, Felipe CoutoThe blood-feeding behavior of Desmodus rotundus made this bat a potential vector of rabies virus and a public health issue. Consequently, the better understanding of its reproductive biology becomes valuable for the development of methods to control its population. In this study, we described morphological aspects of epithelial cells in D. rotundus’ epididymis using light and transmission electron microscopy me...
Pattern of protein expression in the epididymis of Oligoryzomys nigripes (Crice...
Menezes, Tatiana Prata; Hill, Eric; Moura, Arlindo de Alencar; Lobo, Marina D. P.; Breton, Sylvie; Machado-Neves, MarianaIn the epididymis, epithelial cells work in a concerted manner to create a luminal environment for sperm maturation, transport, and storage. However, the cell functions may be affected by anthropogenic factors, causing negative impacts on male fertility. In our study, we describe the pattern of protein expression in the epithelium and luminal fluid from epididymis of Oligoryzomys nigripes, a South American sigm...
Oviduct morphology and estrogen receptors ERα and ERβ expression in captive Chi...
Machado-Neves, Mariana; Assis, Wiviane Alves de; Gomes, Mardelene Geísa; Oliveira, Cleida Aparecida deChinchilla lanigera is a hystricomorph rodent from South America whose reproductive biology presents particular characteristics that distinguishes it from other Rodentia species, such as low reproductive rate, seasonal breeding pattern, and long estrous cycle. Nevertheless, reproductive features in female chinchillas are still poorly investigated, with a scarce knowledge concerning the estrous cycle and the his...